Gastrointestinal stromal tumours at present: an approach to burning questions

Because of their well known origin in gene mutations and a revolutionary therapy by means of molecular targets, gastrointestinal stromal tumours (GIST) constitute a plentiful and paradigmatic model of translational investigation, resulting in an avalanche of exponential growth data. In this article,...

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Bibliographic Details
Published in:Clinical & translational oncology 2010-02, Vol.12 (2), p.100-112
Main Authors: García de Polavieja Carrasco, Manuel, de Juan Ferré, Ana, Mayorga Fernández, Marta
Format: Article
Language:English
Subjects:
Algorithms
Antineoplastic Combined Chemotherapy Protocols - administration & dosage
Biopsy - utilization
Chemotherapy, Adjuvant - utilization
Dose-Response Relationship, Drug
Drug Resistance, Neoplasm - genetics
Educational Series
Gastrointestinal Stromal Tumors - diagnosis
Gastrointestinal Stromal Tumors - genetics
Gastrointestinal Stromal Tumors - pathology
Gastrointestinal Stromal Tumors - therapy
Health Planning Guidelines
Humans
Medicine
Medicine & Public Health
Oncology
Prognosis
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Summary:Because of their well known origin in gene mutations and a revolutionary therapy by means of molecular targets, gastrointestinal stromal tumours (GIST) constitute a plentiful and paradigmatic model of translational investigation, resulting in an avalanche of exponential growth data. In this article, we focus on what we consider to be hot spots in GIST at present. A wide spectrum of events is approached, extending from subtle pathogenic mechanisms at a molecular level (gene mutations and their implications for cell receptors with subsequent activation of signalling pathways) to more practical problems facing diagnosis (molecular markers, role of biopsy), prognosis (risk stratification systems) and different therapeutic aspects (laparoscopic surgery, role of surgery in advanced disease, response criteria, adjuvant and neoadjuvant therapy, treatment for progressing and recurrent disease, therapy directed on mutation analysis and new developments, among others). The review has been endorsed by level of evidence evaluation through a recognised pattern to assist in teaching, and a final summary of recommendations and a management algorithm are included.
ISSN:1699-048X
1699-3055
DOI:10.1007/S12094-010-0476-x