Efficient synthesis of antihistamines clocinizine and chlorcyclizine

A simple and efficient route has been developed for the synthesis of anti-histamine drugs clocinizine and chlorcyclizine. The common intermediate 1-[(4-chloro phenyl) (phenyl)-methyl]-piperazine ( 8 ), is prepared from (4-chlorophenyl) (phenyl)-methanone ( 5 ), in three steps with excellent yields....

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Bibliographic Details
Published in:Medicinal chemistry research 2012-04, Vol.21 (4), p.538-541
Main Authors: Venkat Narsaiah, A., Narsimha, P.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Summary:A simple and efficient route has been developed for the synthesis of anti-histamine drugs clocinizine and chlorcyclizine. The common intermediate 1-[(4-chloro phenyl) (phenyl)-methyl]-piperazine ( 8 ), is prepared from (4-chlorophenyl) (phenyl)-methanone ( 5 ), in three steps with excellent yields. All the reactions proceeded smoothly and the products were also isolated easily.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-011-9556-x