Synthesis and anticancer effects of pongamol derivatives on mitogen signaling and cell cycle kinases

A series of oxazole and pyrazole derivatives of pongamol ( 1 ) were designed and synthesized to examine their anti-cancer activity. The cytotoxicity of these compounds was examined in three different human tumor cell lines, IMR-32, HeLa and Jurkat. Although all compounds tested were quite effective...

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Bibliographic Details
Published in:Medicinal chemistry research 2012-05, Vol.21 (5), p.634-641
Main Authors: Rao, R. Ranga, Chaturvedi, Vishal, Babu, K. Suresh, Reddy, P. Prabhakar, Rao, V. Rama Subba, Sreekanth, P., Sreedhar, A. S., Rao, J. Madhusudana
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Summary:A series of oxazole and pyrazole derivatives of pongamol ( 1 ) were designed and synthesized to examine their anti-cancer activity. The cytotoxicity of these compounds was examined in three different human tumor cell lines, IMR-32, HeLa and Jurkat. Although all compounds tested were quite effective than the pongamol against all the three different types of cancer cell lines examined, the compounds ( 2 ), ( 5 ), and ( 6 ) were found to be the most active compounds of this series. Graphical abstract A series of pongamol derivatives ( 2 – 13 ) (oxazole and Pyrazole derivatives) have been synthesized and tested for their anti-cancer properties against the three human tumor cell lines (IMR32, HeLa, and jurkat).
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-011-9563-y