Synthesis, preliminary cytotoxicity evaluation of new 3-formylchromone hydrazones and phosphorohydrazone derivatives of coumarin and chromone

Reactions of chromone derivatives 1 – 4 with N -substituted hydrazines were described. Hydrazones ( 6 , 7a , 8a – c , 9b – e , 10e , 11e , 12 ) were evaluated for cytotoxicity (MTT test) against HL-60 and NALM-6 leukemia cells. Phosphorohydrazone of 3-formylchromone 8a and hydrazone of 2-amino-3-chr...

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Bibliographic Details
Published in:Medicinal chemistry research 2012-08, Vol.21 (8), p.1861-1868
Main Authors: Łazarenkow, A., Nawrot-Modranka, J., Brzezińska, E., Krajewska, U., Różalski, M.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Summary:Reactions of chromone derivatives 1 – 4 with N -substituted hydrazines were described. Hydrazones ( 6 , 7a , 8a – c , 9b – e , 10e , 11e , 12 ) were evaluated for cytotoxicity (MTT test) against HL-60 and NALM-6 leukemia cells. Phosphorohydrazone of 3-formylchromone 8a and hydrazone of 2-amino-3-chromone derivative 11e showed appreciable cytotoxicity. The cytotoxicity indices of 8a , 11e , and 12 were higher on drug-resistant HL-60 ADR cells in comparison to HL-60. Compounds 8a and 11e were tested for their ability to induce cytochrome c translocation from mitochondria to cytosol.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-011-9703-4