Synthesis and antimycobacterial activities of some new N-acylhydrazone and thiosemicarbazide derivatives of 6-methyl-4,5-dihydropyridazin-3(2H)-one

In this study, twenty-five new 6-methyl-4,5-dihydropyridazin-3(2 H )-one derivatives having N -acylhydrazone and thiosemicarbazide moieties were synthesized. The target compounds were tested for their antimycobacterial activity in vitro against Mycobacterium tuberculosis H 37 R v using the agar dilu...

Full description

Saved in:
Bibliographic Details
Published in:Medicinal chemistry research 2012-09, Vol.21 (9), p.2388-2394
Main Authors: Unsal Tan, Oya, Ozadali, Keriman, Yogeeswari, Perumal, Sriram, Dharmarajan, Balkan, Ayla
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In this study, twenty-five new 6-methyl-4,5-dihydropyridazin-3(2 H )-one derivatives having N -acylhydrazone and thiosemicarbazide moieties were synthesized. The target compounds were tested for their antimycobacterial activity in vitro against Mycobacterium tuberculosis H 37 R v using the agar dilution method. Among the synthesized compounds, N ′-(2,4-dichlorobenzylidene)-2-(3-methyl-6-oxo-5,6-dihydropyridazin-1(4 H )-yl)acetohydrazide 4g was found to be the most active compound with minimum inhibitory concentration of 0.78 μM and was more potent than ethambutol and ciprofloxacin.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-011-9770-6