Synthesis, characterization and antimicrobial activity of novel ethyl 1-(N-substituted)-5-phenyl-1H-pyrazole-4-carboxylate derivatives

In the present study, a novel series of Pyrazole derivatives (3a – m) were synthesized by condensing ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate with different aromatic and aliphatic hydrazines. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral studi...

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Bibliographic Details
Published in:Medicinal chemistry research 2012-09, Vol.21 (9), p.2702-2708
Main Authors: Chandrakantha, B., Isloor, Arun M., Shetty, Prakash, Isloor, Shrikrishna, Malladi, Shridhar, Fun, Hoong Kun
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Summary:In the present study, a novel series of Pyrazole derivatives (3a – m) were synthesized by condensing ethyl-3-(dimethylamino)-2-(phenylcarbonyl)prop-2-enoate with different aromatic and aliphatic hydrazines. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral studies as well as by C, H, and N analyses. All the newly synthesized compounds were screened for their antibacterial properties against Staphylococcus aureus, Bacillus subtilis, Escherichia coli , and Pseudomonas aeruginosa . Among the screened samples, 3c , 3f , 3k, and 3l have showed excellent antibacterial activity against all the tested bacterial strains as compared to the standard drug Ceftriaxone. Few of the compounds were found to be biologically potent. Molecular structure of compound 3i was confirmed by single crystal X-ray analysis.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-011-9796-9