In silico biological activity of steroids from the marine sponge Axinella carteri

The steroidal composition of the marine sponge Axinella carteri , collected from Lakshadweep archipelago in the Arabian Sea was found to be a prolific source for a variety of rare steroids. The GC–MS study afforded us with the occurrence of 8 steroids belonging to four different types of nucleus, in...

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Bibliographic Details
Published in:Medicinal chemistry research 2013-03, Vol.22 (3), p.1142-1146
Main Authors: Anuradha, V., Byju, K., Emilda, Rosmine, Anu, Gopinath, Nair, S. M., Chandramohanakumar, N., Peter, K. J. Prashob, Kumar, T. R. Gireesh, Vasundhara, G.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Summary:The steroidal composition of the marine sponge Axinella carteri , collected from Lakshadweep archipelago in the Arabian Sea was found to be a prolific source for a variety of rare steroids. The GC–MS study afforded us with the occurrence of 8 steroids belonging to four different types of nucleus, including the unique occurrence of an unconventional steroid A-norcholestan-2-one in Axinella carteri . The biological activity was predicted using the soft ware PASS. It was found that majority of the steroids extracted from Axinella carteri exhibited the potential of being agonistic to nerve growth factor (NGF).
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-012-0119-6