Mild and highly efficient copper (II) sulfate catalyzed one pot synthesis of 2-aryl benzimidazole using atmospheric air as an oxidant and its antibacterial study

A simple, efficient, and environmentally benign method has been developed for the synthesis of 2-substituted benzimidazole using one pot reaction of o -phenylenediamine with substituted aldehydes in good to excellent yields under mild conditions using low catalyst loading (CuSO 4 as the selective ca...

Full description

Saved in:
Bibliographic Details
Published in:Medicinal chemistry research 2013-04, Vol.22 (4), p.1788-1794
Main Authors: Jain, Raginee, Agarwal, D. D., Sahu, Pramod K., Selvam, D. Thava, Sharma, Yogesh, Gupta, Ruchi, Prakash, Archana
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A simple, efficient, and environmentally benign method has been developed for the synthesis of 2-substituted benzimidazole using one pot reaction of o -phenylenediamine with substituted aldehydes in good to excellent yields under mild conditions using low catalyst loading (CuSO 4 as the selective catalyst) and atmospheric air as an oxidant. All synthesized compounds were evaluated for their in vitro anti bacterial activity against six microorganisms: Staphylococcus aureus (ATCC 11632) , Streptococcus feacalis (clinically isolated) , Bacillus cerus (MTCC 7350) , Escherichia coli (ATCC 35218), Salmonella typhi (ATCC15499), and Pseudomonas aeruginosa (ATCC 23564). It was observed that all compounds exhibited good to moderate activity as compared to standard drug. The easy setup and purification procedure of this sustainable method and biological importance makes it appealing for bulk industry applications.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-012-0178-8