5-Nitro-heteroarylidene analogs of 2-thiazolylimino-4-thiazolidinones as a novel series of antibacterial agents

In the pursuit of novel antibacterial agents with the 2-thiazolylimino-4-thiazolidinone as a core structure, a series of 5-nitro-heteroarylidene and 5-(2-oxoindolin-3-ylidene) analogs of 2-thiazolylimino-5-arylidene-4-thiazolidinone were synthesized and their antibacterial activities were evaluated...

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Bibliographic Details
Published in:Medicinal chemistry research 2013-05, Vol.22 (5), p.2293-2302
Main Authors: Hosseinzadeh, Nouraddin, Hasani, Mohammad, Foroumadi, Alireza, Nadri, Hamid, Emami, Saeed, Samadi, Nasrin, Faramarzi, Mohammad Ali, Saniee, Parastoo, Siavoshi, Farideh, Abadian, Neda, Mahmoudjanlou, Yasaman, Sakhteman, Amirhossein, Moradi, Alireza, Shafiee, Abbas
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Summary:In the pursuit of novel antibacterial agents with the 2-thiazolylimino-4-thiazolidinone as a core structure, a series of 5-nitro-heteroarylidene and 5-(2-oxoindolin-3-ylidene) analogs of 2-thiazolylimino-5-arylidene-4-thiazolidinone were synthesized and their antibacterial activities were evaluated against some strains of Gram-positive and Gram-negative bacteria, as well as Helicobacter pylori strains. Biological data indicated that 5-nitrofuran analog 5a and 5-nitroimidazole analog 7a containing no substitutions on the thiazole ring were the most potent compounds.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-012-0224-6