Synthesis antimicrobial and anticancer activity of N′-arylmethylidene-piperazine-1-carbothiohydrazide

Ten newly synthesized thiosemicarbazones of piperazine ( 3a – 3j ) were evaluated for their antibacterial and antifungal activity against non-pathogenic strains of Escherichia coli (NCIM 2068), Klebsiella pneumonia (NCIM 2957), Staphylococcus aureus (NCIM 2079), and Bacillus subtilis (NCIM 2921); pa...

Full description

Saved in:
Bibliographic Details
Published in:Medicinal chemistry research 2013-06, Vol.22 (6), p.2802-2808
Main Authors: Kulandaivelu, Umasankar, Shireesha, Boyapati, Mahesh, Chidara, Vidyasagar, Jannu Vincent, Rao, Tadikonda Rama, Jayaveera, K. N., Saiko, Philipp, Graser, Geraldine, Szekeres, Thomas, Jayaprakash, Venkatesan
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ten newly synthesized thiosemicarbazones of piperazine ( 3a – 3j ) were evaluated for their antibacterial and antifungal activity against non-pathogenic strains of Escherichia coli (NCIM 2068), Klebsiella pneumonia (NCIM 2957), Staphylococcus aureus (NCIM 2079), and Bacillus subtilis (NCIM 2921); pathogenic strains of Vibrio cholerae , protease , Candida albicans and Aspergillus niger. All the 10 compounds ( 3a – 3j ) were found to be better than Ciprofloxacin against B. subtilis and four molecules ( 3c , 3d, 3e, and 3h) against S. aureus. Compound 3j, a derivative of benzophenone, has been identified as a potent and promising candidate against C. albicans. The compounds were also evaluated for their anticancer activity against HBL-100 and HL60 cell lines. Compound 3a, a p -hydroxy benzaldehyde derivative, has been identified as a potent and promising candidate.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-012-0279-4