Synthesis antimicrobial and anticancer activity of N′-arylmethylidene-piperazine-1-carbothiohydrazide

Ten newly synthesized thiosemicarbazones of piperazine ( 3a – 3j ) were evaluated for their antibacterial and antifungal activity against non-pathogenic strains of Escherichia coli (NCIM 2068), Klebsiella pneumonia (NCIM 2957), Staphylococcus aureus (NCIM 2079), and Bacillus subtilis (NCIM 2921); pa...

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Published in:Medicinal chemistry research 2013-06, Vol.22 (6), p.2802-2808
Main Authors: Kulandaivelu, Umasankar, Shireesha, Boyapati, Mahesh, Chidara, Vidyasagar, Jannu Vincent, Rao, Tadikonda Rama, Jayaveera, K. N., Saiko, Philipp, Graser, Geraldine, Szekeres, Thomas, Jayaprakash, Venkatesan
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Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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cited_by cdi_FETCH-LOGICAL-c288t-3563d49948966130e2cb43156cb4967e4d4a9ee0f7869ccbf6996dcd3c62173e3
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container_title Medicinal chemistry research
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creator Kulandaivelu, Umasankar
Shireesha, Boyapati
Mahesh, Chidara
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Saiko, Philipp
Graser, Geraldine
Szekeres, Thomas
Jayaprakash, Venkatesan
description Ten newly synthesized thiosemicarbazones of piperazine ( 3a – 3j ) were evaluated for their antibacterial and antifungal activity against non-pathogenic strains of Escherichia coli (NCIM 2068), Klebsiella pneumonia (NCIM 2957), Staphylococcus aureus (NCIM 2079), and Bacillus subtilis (NCIM 2921); pathogenic strains of Vibrio cholerae , protease , Candida albicans and Aspergillus niger. All the 10 compounds ( 3a – 3j ) were found to be better than Ciprofloxacin against B. subtilis and four molecules ( 3c , 3d, 3e, and 3h) against S. aureus. Compound 3j, a derivative of benzophenone, has been identified as a potent and promising candidate against C. albicans. The compounds were also evaluated for their anticancer activity against HBL-100 and HL60 cell lines. Compound 3a, a p -hydroxy benzaldehyde derivative, has been identified as a potent and promising candidate.
doi_str_mv 10.1007/s00044-012-0279-4
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subjects Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
title Synthesis antimicrobial and anticancer activity of N′-arylmethylidene-piperazine-1-carbothiohydrazide
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