Synthesis of some new indolo[2,3-c]isoquinolinyl pyrazoles, -1,3,4-oxadiazoles and their biological activities

• Published in: Medicinal chemistry research 2013-08, Vol.22 (8), p.3787-3793
• Main Authors: Saundane, Anand R., Verma, Vaijinath A., Vijaykumar, Katkar
• Format: Article
• Language: English
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Original Research; Pharmacology/Toxicology
• ISSN: 1054-2523; 1554-8120
• DOI: 10.1007/s00044-012-0366-6

A new series of novel compounds [10-substituted 6 H, 7 H -indolo[2,3-c]isoquinolin-5-one-6-yl]carbohydrazides ( 3a–c ), 1-[10-substituted 6 H, 7 H -indolo[2,3-c]isoquinolin-5-one-6-yl]fomyl-, -3′,5′-dimethylpyrazoles ( 4a–c ), -3′,5′-diphenylpyrazoles ( 5a–c ), -3′-methylpyrazol-5′-ones ( 6a–c ) and -1′,3′,4′-oxidiazole-2′-thiones ( 7a–c ) linked to indoloisoquinoline at position-6 through formyl bridge was prepared. The structures of these newly synthesized compounds were confirmed by their spectral studies and elemental analysis. These compounds have been screened for their antimicrobial and antioxidant activities. Compounds 4a , 4b , 5a, 5b , 5c , 6b , 7a, and 7c exhibited the maximum zone of inhibition against A. niger, A. flavus , and A. fumigatus. Compounds 4a , 5a , 5c , 6b , 6c , 7a, and 7b showed good antibacterial activity. Compounds 4b , 4c , 5b , 5c, 6a , 6b, 7a , 7b , and 7c showed good radical scavenging activity compared with standards.