Synthesis of biphenyl derivatives as ACE and α-amylase inhibitors

Angiotensin converting enzyme (ACE) and α-amylase inhibitors were synthesized using 4′-(bromomethyl)-biphenyl-2-carbonitrile 1 and various cyclic secondary amines ( a – h ). The nitrile group appended to biphenyl was converted into tetrazole 3a – 3h and the tetrazole was ring transformed into 1,3,4-...

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Bibliographic Details
Published in:Medicinal chemistry research 2013-12, Vol.22 (12), p.5868-5877
Main Authors: Meti, Gangadhar Yamanappa, Kamble, Ravindra Ramappa, Biradar, Dharesh Bhimaraya, Margankop, Sheetal Babu
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Summary:Angiotensin converting enzyme (ACE) and α-amylase inhibitors were synthesized using 4′-(bromomethyl)-biphenyl-2-carbonitrile 1 and various cyclic secondary amines ( a – h ). The nitrile group appended to biphenyl was converted into tetrazole 3a – 3h and the tetrazole was ring transformed into 1,3,4-oxadiazole derivatives 4a – 4h . Some of the compounds have exhibited significant ACE and α-amylase inhibition.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-013-0574-8