Synthesis and evaluation of anti-inflammatory and analgesic activity of some substituted thiazolyl and thaizolidinonyl tetrahydronapthalene derivatives

A new series of 1,2,3,4-tetrahydronaphthalen-6-yl-thiazole and thiazolidinone derivatives were synthesized. Twenty four of the newly synthesized compounds were evaluated for their anti-inflammatory and analgesic activity. The study exhibited that the derivatives 7b and 11c produced equipotent anti-i...

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Bibliographic Details
Published in:Medicinal chemistry research 2014-07, Vol.23 (7), p.3418-3435
Main Authors: Haiba, Mogedda E., Abd El-Karim, Somaia S., Gouhar, Rasha S., El-Zahar, Magdy I., El-Awdan, Sally A.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Summary:A new series of 1,2,3,4-tetrahydronaphthalen-6-yl-thiazole and thiazolidinone derivatives were synthesized. Twenty four of the newly synthesized compounds were evaluated for their anti-inflammatory and analgesic activity. The study exhibited that the derivatives 7b and 11c produced equipotent anti-inflammatory activity to that of the reference drug indomethacin with faster onset of action. Meanwhile, the compounds 1b , 1d , 6 , 10c , 12c , 12e exhibited interesting dual anti-inflammatory and analgesic activity. The thiazolo-coumarin derivative 6 could be identified as the most biologically active member within this study with a significant dual anti-inflammatory and analgesic activity in comparison with indomethacin. The study of ulcerogenic effects proved that all of the tested compounds revealed super GIT safety profile in the experimental rats.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-014-0926-z