Recyclable CuO nanoparticles-catalyzed synthesis of novel-2,5-disubstituted 1,3,4-oxadiazoles as antiproliferative, antibacterial, and antifungal agents

A series of new 2,5-disubstituted 1,3,4-oxadiazoles have been conveniently synthesized through an oxidative C–O coupling by direct C–H bond activation of N -aroyl- N -arylidinehydrazines using a catalytic quantity of CuO nanoparticles. Twenty compounds have been synthesized in good to excellent yiel...

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Bibliographic Details
Published in:Medicinal chemistry research 2014-10, Vol.23 (10), p.4579-4594
Main Authors: Murty, M. S. R., Penthala, Raju, Buddana, Sudheer Kumar, Prakasham, R. S., Das, Pompi, Polepalli, Sowjanya, Jain, N., Bojja, Sreedhar
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Summary:A series of new 2,5-disubstituted 1,3,4-oxadiazoles have been conveniently synthesized through an oxidative C–O coupling by direct C–H bond activation of N -aroyl- N -arylidinehydrazines using a catalytic quantity of CuO nanoparticles. Twenty compounds have been synthesized in good to excellent yields (75–90 %). All the synthesized compounds were evaluated for their in vitro antiproliferative, antibacterial, and antifungal activity. Compounds 8d and 10d are more promising antiproliferative agents with IC 50 value of 3.66 and 3.89 µM in MCF-7 cell line, and compounds 8a and 10a were showed more potent antifungal activity than standard drug.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-014-1025-x