Chromenone and quinolinone derivatives as potent antioxidant agents

The antioxidant activity (AOA) of three different classes of phenolic compounds viz chromen-2-ones, chromen-4-ones, and quinolin-2-ones was systematically studied using DPPH, ABTS, FRAP, and in vitro lipid peroxidation inhibition assays. The effect of incorporation of hydrophobic group on AOA was al...

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Bibliographic Details
Published in:Medicinal chemistry research 2014-11, Vol.23 (11), p.4907-4914
Main Authors: Vats, Praveen, Hadjimitova, Vera, Yoncheva, Krassimira, Kathuria, Abha, Sharma, Antara, Chand, Karam, Duraisamy, Arul J., Sharma, Alpesh K., Sharma, Atul K., Saso, Luciano, Sharma, Sunil K.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
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Summary:The antioxidant activity (AOA) of three different classes of phenolic compounds viz chromen-2-ones, chromen-4-ones, and quinolin-2-ones was systematically studied using DPPH, ABTS, FRAP, and in vitro lipid peroxidation inhibition assays. The effect of incorporation of hydrophobic group on AOA was also studied. In DPPH, ABTS, and FRAP assays, the highest AOA was registered for the dihydroxy chromenones among all the phenolic derivatives. Presence of alkyl group led to reduction in AOA in the above three assays. However, in lipid peroxidation inhibition assay for selected compounds, incorporation of alkyl group led to enhancement in AOA. The AOA of few compounds was observed to be more than three times higher in comparison to standard “Trolox” in lipid peroxidation inhibitory assay.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-014-1054-5