Synthesis and evaluation of 29-norcycloartane triterpenoids as α-glucosidase inhibitors

A series of oxygen and nitrogen derivatives of 29-norcycloartane triterpenoids have been synthesized on the basis of cyclomusalenone isolated from Musa balbisiana Colla. The structures of new compounds have been established by an NMR spectroscopy analysis, and inhibitory activity against α-glucosida...

Full description

Saved in:
Bibliographic Details
Published in:Medicinal chemistry research 2015-05, Vol.24 (5), p.2177-2182
Main Authors: Smirnova, Irina E., Kazakova, Oxana B., Viet, Do Quoc, Thuc, Nguyen Thi, Linh, Pham Thuy, Huong, Do Thi Thu
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Original Research
Pharmacology/Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A series of oxygen and nitrogen derivatives of 29-norcycloartane triterpenoids have been synthesized on the basis of cyclomusalenone isolated from Musa balbisiana Colla. The structures of new compounds have been established by an NMR spectroscopy analysis, and inhibitory activity against α-glucosidase was evaluated. Among tested compounds, 2,3-isoxazolocyclomusalenone is discovered as a new potent α-glucosidase inhibitor with IC 50 value 20.4 μM being 30- and 20-fold more active than initial cyclomusalenone and marketed drug acarbose. Graphical Abstract
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-014-1292-6