Diabetic ketoacidosis at the onset of type 1 diabetes is associated with future HbA1c levels

Aims/hypothesis We investigated the long-term impact of diabetic ketoacidosis (DKA) at onset on metabolic regulation and residual beta cell function in a Danish population with type 1 diabetes. Methods The study is based on data from DanDiabKids, a Danish national diabetes register for children. The...

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Bibliographic Details
Published in:Diabetologia 2013-05, Vol.56 (5), p.995-1003
Main Authors: Fredheim, S., Johannesen, J., Johansen, A., Lyngsøe, L., Rida, H., Andersen, M. L. M., Lauridsen, M. H., Hertz, B., Birkebæk, N. H., Olsen, B., Mortensen, H. B., Svensson, J.
Format: Article
Language:English
Subjects:
Adolescent
Biological and medical sciences
Biomarkers - blood
Child
Child, Preschool
Denmark - epidemiology
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - diagnosis
Diabetes Mellitus, Type 1 - drug therapy
Diabetes Mellitus, Type 1 - physiopathology
Diabetes. Impaired glucose tolerance
Diabetic Ketoacidosis - epidemiology
Diabetic Ketoacidosis - etiology
Diabetic Ketoacidosis - prevention & control
Drug Monitoring
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Glycated Hemoglobin A - analysis
Human Physiology
Humans
Hyperglycemia - epidemiology
Hyperglycemia - etiology
Hyperglycemia - prevention & control
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - therapeutic use
Insulin - administration & dosage
Insulin - blood
Insulin - metabolism
Insulin - therapeutic use
Insulin Infusion Systems
Insulin Secretion
Insulin-Secreting Cells - metabolism
Internal Medicine
Longitudinal Studies
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Prevalence
Prognosis
Registries
Severity of Illness Index
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Summary:Aims/hypothesis We investigated the long-term impact of diabetic ketoacidosis (DKA) at onset on metabolic regulation and residual beta cell function in a Danish population with type 1 diabetes. Methods The study is based on data from DanDiabKids, a Danish national diabetes register for children. The register provides clinical and biochemical data on patients with type 1 diabetes diagnosed in 1996–2009 and then followed-up until 1 January 2012. Repeated-measurement models were used as statistical methods. Results The study population comprised 2,964 children
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-013-2850-z