Porphyrin studies in TCDD-exposed workers

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been shown to inhibit uroporphyrinogen decarboxylase activity resulting in chronic hepatic porphyria. From a cross-sectional study of 170 workers in chemical industry 68 showed elevated coproporphyrin levels, interpreted as secondary coproporphyrinuria....

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Bibliographic Details
Published in:Archives of toxicology 1994-09, Vol.68 (9), p.595-598
Main Authors: JUNG, D, KONIETZKO, J, REILL-KONIETZKO, G, MUTTRAY, A, ZIMMERMANN-HÖLZ, H.-J, DOSS, M, BECK, H, EDLER, L, KOPP-SCHNEIDER, A
Format: Article
Language:English
Subjects:
Adipose Tissue - chemistry
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Chemical Industry
Facial Dermatoses - epidemiology
Humans
Male
Medical sciences
Occupational Diseases - epidemiology
Occupational Exposure
Polychlorinated Dibenzodioxins - analysis
Polychlorinated Dibenzodioxins - pharmacology
Porphyrias, Hepatic - epidemiology
Porphyrins - metabolism
Protoporphyrins - blood
Toxicology
Various organic compounds
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Summary:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) has been shown to inhibit uroporphyrinogen decarboxylase activity resulting in chronic hepatic porphyria. From a cross-sectional study of 170 workers in chemical industry 68 showed elevated coproporphyrin levels, interpreted as secondary coproporphyrinuria. Three persons suffered from chronic hepatic porphyria in subclinical stages. None of the workers showed an overt porphyria cutanea tarda. A low-grade zinc protoporphyrinemia was observed in three persons. Forty-three of the 170 workers were evaluable for investigating the effect of TCDD on porphyrin levels. No significant correlation was found between TCDD concentration in adipose tissue and the level of uroporphyrin and coproporphyrin. The influence of a chloracne history is described.
ISSN:0340-5761
1432-0738
DOI:10.1007/s002040050120