A review of the DNA standard reference materials developed by the National Institute of Standards and technology

The Standard Reference Materials Program at the US National Institute of Standards and Technology (NIST) has three human DNA standard reference materials (SRM 2390, SRM 2391a, and SRM 2392) currently available [1, 2]. Both the DNA profiling SRM 2390 and the polymerase chain reaction (PCR)-based DNA...

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Bibliographic Details
Published in:Analytical and bioanalytical chemistry 2001-06, Vol.370 (2-3), p.213-219
Main Authors: LEVIN, B. C, CHENG, H, KLINE, M. C, REDMAN, J. W, RICHIE, K. L
Format: Article
Language:English
Subjects:
Analytical biochemistry: general aspects, technics, instrumentation
Analytical chemistry
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Chemistry
Criminal investigation
Diagnostic equipment (Medical)
DNA - analysis
DNA - standards
DNA, Mitochondrial - analysis
DNA, Mitochondrial - standards
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
General, instrumentation
Genome, Human
Humans
Mitochondrial DNA
Polymerase Chain Reaction - methods
Polymerase Chain Reaction - standards
Quality control
Reference Standards
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Summary:The Standard Reference Materials Program at the US National Institute of Standards and Technology (NIST) has three human DNA standard reference materials (SRM 2390, SRM 2391a, and SRM 2392) currently available [1, 2]. Both the DNA profiling SRM 2390 and the polymerase chain reaction (PCR)-based DNA profiling SRM 2391a are intended for use in forensic and paternity identifications, for instructional law enforcement, or for non-clinical research purposes and are not intended for clinical diagnostics. The mitochondrial DNA (mtDNA) SRM 2392 is to provide standardization and quality control when performing PCR and sequencing any segment or the entire 16,569 base pairs that comprise human mitochondrial DNA. SRM 2392 is designed for use by the forensic, medical, and toxicological communities for human identification, disease diagnosis or mutation detection.
ISSN:0937-0633
1618-2642
1432-1130
DOI:10.1007/s002160100792