Oculo-bulbar myasthenia gravis induced by cytokine treatment of a patient with metastasized renal cell carcinoma

The occurrence of autoimmune diseases or deterioration of pre-existing disorders has recently been described after cytokine treatment. The present report gives evidence for acquired myasthenia gravis induced by externally administered interferon-alpha and interleukin-2 in a patient with metastasized...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical pharmacology 1996, Vol.50 (6), p.471-473
Main Authors: Rohde, D, Sliwka, U, Schweizer, K, Jakse, G
Format: Article
Language:English
Subjects:
Carcinoma, Renal Cell - drug therapy
Cytokines - adverse effects
Cytokines - therapeutic use
Eyelid Diseases - chemically induced
Eyelid Diseases - immunology
Humans
Interferon-alpha - adverse effects
Interferon-alpha - therapeutic use
Interleukin-2 - adverse effects
Interleukin-2 - therapeutic use
Kidney Neoplasms - drug therapy
Male
Middle Aged
Myasthenia Gravis - chemically induced
Myasthenia Gravis - immunology
Receptors, Cholinergic - immunology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The occurrence of autoimmune diseases or deterioration of pre-existing disorders has recently been described after cytokine treatment. The present report gives evidence for acquired myasthenia gravis induced by externally administered interferon-alpha and interleukin-2 in a patient with metastasized renal cell carcinoma. Electromyographic investigations did not reveal generalised myasthenia gravis. However, a highly elevated titre of antibodies against the human acetylcholine receptor and a significant improvement in clinical symptoms during therapy with anticholinesterase drugs, combined with a decremental response in electronystagmography, indicated an intermittent mainly oculo-bulbar form of myasthenia gravis.
ISSN:0031-6970
1432-1041
DOI:10.1007/s002280050143