The facial keloid: a comparison of treatment outcome between intralesional steroid injection and excision combined with radiotherapy

Background Various conflicting claims of superiority of particular treatment modalities or regimens abound in the literature for the treatment of keloid. This study was designed to determine the more reliable method to flatten keloid between intralesional triamcinolone injection and excision combine...

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Published in:European journal of plastic surgery 2014-07, Vol.37 (7), p.361-366
Main Authors: Aluko-Olokun, Bayo, Olaitan, Ademola Abayomi, Ladeinde, Akinola Ladipo, Oginni, Fadekemi Olufunmilayo
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Medicine & Public Health
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Plastic Surgery
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Olaitan, Ademola Abayomi
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description Background Various conflicting claims of superiority of particular treatment modalities or regimens abound in the literature for the treatment of keloid. This study was designed to determine the more reliable method to flatten keloid between intralesional triamcinolone injection and excision combined with radiotherapy. Methods One hundred and seven consecutive patients presenting with facial keloids were alternately allocated into two groups. Group A was managed by intralesional injection of 10 mg per linear centimetre of keloid scar, fortnightly for a maximum of 6 months, while group B underwent excision combined with 16 Gray of radiation administered in four fractions, in as many consecutive days, commencing immediately preoperatively. Results Flattening of lesion was achieved in 81 % of scars managed with triamcinolone, while 58 % of those treated by excision combined with radiotherapy remained flat during the course of study. The difference between the two results was statistically significant ( P  
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This study was designed to determine the more reliable method to flatten keloid between intralesional triamcinolone injection and excision combined with radiotherapy. Methods One hundred and seven consecutive patients presenting with facial keloids were alternately allocated into two groups. Group A was managed by intralesional injection of 10 mg per linear centimetre of keloid scar, fortnightly for a maximum of 6 months, while group B underwent excision combined with 16 Gray of radiation administered in four fractions, in as many consecutive days, commencing immediately preoperatively. Results Flattening of lesion was achieved in 81 % of scars managed with triamcinolone, while 58 % of those treated by excision combined with radiotherapy remained flat during the course of study. The difference between the two results was statistically significant ( P  &lt; 0.01). Conclusions Intralesional injection of triamcinolone is significantly more efficacious than excision combined with radiotherapy in the management of facial keloids. 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This study was designed to determine the more reliable method to flatten keloid between intralesional triamcinolone injection and excision combined with radiotherapy. Methods One hundred and seven consecutive patients presenting with facial keloids were alternately allocated into two groups. Group A was managed by intralesional injection of 10 mg per linear centimetre of keloid scar, fortnightly for a maximum of 6 months, while group B underwent excision combined with 16 Gray of radiation administered in four fractions, in as many consecutive days, commencing immediately preoperatively. Results Flattening of lesion was achieved in 81 % of scars managed with triamcinolone, while 58 % of those treated by excision combined with radiotherapy remained flat during the course of study. The difference between the two results was statistically significant ( P  &lt; 0.01). Conclusions Intralesional injection of triamcinolone is significantly more efficacious than excision combined with radiotherapy in the management of facial keloids. 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This study was designed to determine the more reliable method to flatten keloid between intralesional triamcinolone injection and excision combined with radiotherapy. Methods One hundred and seven consecutive patients presenting with facial keloids were alternately allocated into two groups. Group A was managed by intralesional injection of 10 mg per linear centimetre of keloid scar, fortnightly for a maximum of 6 months, while group B underwent excision combined with 16 Gray of radiation administered in four fractions, in as many consecutive days, commencing immediately preoperatively. Results Flattening of lesion was achieved in 81 % of scars managed with triamcinolone, while 58 % of those treated by excision combined with radiotherapy remained flat during the course of study. The difference between the two results was statistically significant ( P  &lt; 0.01). 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subjects Medicine
Medicine & Public Health
Original Paper
Plastic Surgery
title The facial keloid: a comparison of treatment outcome between intralesional steroid injection and excision combined with radiotherapy
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