How important are mean platelet volume and neutrophil values in diabetic foot amputation decision?

Background Previous studies have shown mean platelet volume (MPV) levels to be an important biomarker in the formation of foot ulcers in diabetic patients. The aim here was to show whether MPV, monocyte, platelet, and neutrophil levels could guide diabetic foot amputation. Methods Two groups of pati...

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Bibliographic Details
Published in:European journal of plastic surgery 2021-08, Vol.44 (4), p.507-510
Main Authors: Kapukaya, Rana, Kapukaya, Ahmet, Keklikcioglu, Burak, Özdemir, Asena Ayça
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Original Paper
Plastic Surgery
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Summary:Background Previous studies have shown mean platelet volume (MPV) levels to be an important biomarker in the formation of foot ulcers in diabetic patients. The aim here was to show whether MPV, monocyte, platelet, and neutrophil levels could guide diabetic foot amputation. Methods Two groups of patients diagnosed with type 2 diabetes and homogeneous in terms of age, sex, diabetes duration, body mass index (BMI), and hemoglobulinA1C (HbA1C) levels were included. The first group consisted of 36 patients with amputation, and the second group consisted of 30 patients with ulceration but no indication for amputation. Besides overall demographic characteristics, preoperative HbA1C, MPV, platelet, monocyte, and neutrophil levels were determined in both groups. Results The amputated group had higher MPV and neutrophil levels than the non-amputated control group ( p  = 0.028 and p  
ISSN:0930-343X
1435-0130
DOI:10.1007/s00238-020-01773-2