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Utility of indocyanine green angiography in delaying breast reconstruction postmastectomy
Background Perfusion mapping with indocyanine green angiography (ICGA) in breast reconstruction can change intraoperative plans and reduce the risk of flap necrosis. We evaluated the utility of ICGA in the decision to delay reconstruction postmastectomy and its predictive power for necrosis. Methods...
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Published in: | European journal of plastic surgery 2022-10, Vol.45 (5), p.755-761 |
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creator | Nguyen, Chu Luan Liu, Yi Hui Angella Lata, Tahmina Easwaralingam, Neshanth Seah, Jue Li Chan, Carina Cao, Felicia Azimi, Farhad Mak, Cindy Pulitano, Carlo Warrier, Sanjay Kumar |
description | Background
Perfusion mapping with indocyanine green angiography (ICGA) in breast reconstruction can change intraoperative plans and reduce the risk of flap necrosis. We evaluated the utility of ICGA in the decision to delay reconstruction postmastectomy and its predictive power for necrosis.
Methods
Single-institution retrospective study of implant-based breast reconstructions following mastectomy using ICGA from 2015 to 2021. A decision was made to proceed with immediate reconstruction or delay reconstruction based on clinical assessment and perfusion analysis. Incidence of complications in the immediate and delayed cohorts were assessed. Intraoperative ICGA perfusion values were correlated with postoperative outcomes to calculate diagnostic accuracy.
Results
Three hundred twenty breast reconstructions were performed. Two hundred fifty-nine of these underwent immediate reconstruction, while 61 underwent delayed reconstruction due to poor perfusion. Median time between mastectomy and delayed reconstruction was 7.3 days (range, 4–21 days). All 8 cases (3.1%) of necrosis were in the immediate cohort. Cases of necrosis had significantly lower intraoperative ICGA perfusion values compared to cases without necrosis (absolute values 13.1 versus 27.1 units,
p
= 0.017). Increasing our ICGA cut-off score for necrosis from 14 to 22 units would have increased sensitivity from 63 to 100% but reduced specificity from 70 to 48%.
Conclusions
Delayed breast reconstruction due to poor perfusion on ICGA resulted in no cases of necrosis. A higher ICGA cut-off score for predicting necrosis is more sensitive but less specific. ICGA is useful as a supplement rather than a substitute for clinical assessment in flap perfusion evaluation.
Level of Evidence Level III, Risk / Diagnostic Study. |
doi_str_mv | 10.1007/s00238-022-01944-3 |
format | article |
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Perfusion mapping with indocyanine green angiography (ICGA) in breast reconstruction can change intraoperative plans and reduce the risk of flap necrosis. We evaluated the utility of ICGA in the decision to delay reconstruction postmastectomy and its predictive power for necrosis.
Methods
Single-institution retrospective study of implant-based breast reconstructions following mastectomy using ICGA from 2015 to 2021. A decision was made to proceed with immediate reconstruction or delay reconstruction based on clinical assessment and perfusion analysis. Incidence of complications in the immediate and delayed cohorts were assessed. Intraoperative ICGA perfusion values were correlated with postoperative outcomes to calculate diagnostic accuracy.
Results
Three hundred twenty breast reconstructions were performed. Two hundred fifty-nine of these underwent immediate reconstruction, while 61 underwent delayed reconstruction due to poor perfusion. Median time between mastectomy and delayed reconstruction was 7.3 days (range, 4–21 days). All 8 cases (3.1%) of necrosis were in the immediate cohort. Cases of necrosis had significantly lower intraoperative ICGA perfusion values compared to cases without necrosis (absolute values 13.1 versus 27.1 units,
p
= 0.017). Increasing our ICGA cut-off score for necrosis from 14 to 22 units would have increased sensitivity from 63 to 100% but reduced specificity from 70 to 48%.
Conclusions
Delayed breast reconstruction due to poor perfusion on ICGA resulted in no cases of necrosis. A higher ICGA cut-off score for predicting necrosis is more sensitive but less specific. ICGA is useful as a supplement rather than a substitute for clinical assessment in flap perfusion evaluation.
Level of Evidence Level III, Risk / Diagnostic Study.</description><identifier>ISSN: 1435-0130</identifier><identifier>EISSN: 1435-0130</identifier><identifier>DOI: 10.1007/s00238-022-01944-3</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Medicine ; Medicine & Public Health ; Original Paper ; Plastic Surgery</subject><ispartof>European journal of plastic surgery, 2022-10, Vol.45 (5), p.755-761</ispartof><rights>The Author(s) 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-75a8dac1187b96f3a3e6e7a55d5edda10e68903e1d0d4f8ed7382390aba9dccf3</citedby><cites>FETCH-LOGICAL-c335t-75a8dac1187b96f3a3e6e7a55d5edda10e68903e1d0d4f8ed7382390aba9dccf3</cites><orcidid>0000-0002-6154-9369</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Nguyen, Chu Luan</creatorcontrib><creatorcontrib>Liu, Yi Hui Angella</creatorcontrib><creatorcontrib>Lata, Tahmina</creatorcontrib><creatorcontrib>Easwaralingam, Neshanth</creatorcontrib><creatorcontrib>Seah, Jue Li</creatorcontrib><creatorcontrib>Chan, Carina</creatorcontrib><creatorcontrib>Cao, Felicia</creatorcontrib><creatorcontrib>Azimi, Farhad</creatorcontrib><creatorcontrib>Mak, Cindy</creatorcontrib><creatorcontrib>Pulitano, Carlo</creatorcontrib><creatorcontrib>Warrier, Sanjay Kumar</creatorcontrib><title>Utility of indocyanine green angiography in delaying breast reconstruction postmastectomy</title><title>European journal of plastic surgery</title><addtitle>Eur J Plast Surg</addtitle><description>Background
Perfusion mapping with indocyanine green angiography (ICGA) in breast reconstruction can change intraoperative plans and reduce the risk of flap necrosis. We evaluated the utility of ICGA in the decision to delay reconstruction postmastectomy and its predictive power for necrosis.
Methods
Single-institution retrospective study of implant-based breast reconstructions following mastectomy using ICGA from 2015 to 2021. A decision was made to proceed with immediate reconstruction or delay reconstruction based on clinical assessment and perfusion analysis. Incidence of complications in the immediate and delayed cohorts were assessed. Intraoperative ICGA perfusion values were correlated with postoperative outcomes to calculate diagnostic accuracy.
Results
Three hundred twenty breast reconstructions were performed. Two hundred fifty-nine of these underwent immediate reconstruction, while 61 underwent delayed reconstruction due to poor perfusion. Median time between mastectomy and delayed reconstruction was 7.3 days (range, 4–21 days). All 8 cases (3.1%) of necrosis were in the immediate cohort. Cases of necrosis had significantly lower intraoperative ICGA perfusion values compared to cases without necrosis (absolute values 13.1 versus 27.1 units,
p
= 0.017). Increasing our ICGA cut-off score for necrosis from 14 to 22 units would have increased sensitivity from 63 to 100% but reduced specificity from 70 to 48%.
Conclusions
Delayed breast reconstruction due to poor perfusion on ICGA resulted in no cases of necrosis. A higher ICGA cut-off score for predicting necrosis is more sensitive but less specific. ICGA is useful as a supplement rather than a substitute for clinical assessment in flap perfusion evaluation.
Level of Evidence Level III, Risk / Diagnostic Study.</description><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Paper</subject><subject>Plastic Surgery</subject><issn>1435-0130</issn><issn>1435-0130</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kL1OwzAQgC0EEqXwAkx-gcA5FzfJiCr-pEosdGCyXPsSXLV2ZbtD3h5DGZiY7vc7nT7GbgXcCYD2PgHU2FVQ1xWIvmkqPGMz0aAsJcL5n_ySXaW0BRCyh2bGPtbZ7VyeeBi48zaYSXvniY-RyHPtRxfGqA-fU5lySzs9OT_yTSSdMo9kgk85Hk12wfNDSHlf-mRy2E_X7GLQu0Q3v3HO1k-P78uXavX2_Lp8WFUGUeaqlbqz2gjRtZt-MaBGWlCrpbSSrNUCaNH1gCQs2GboyLbY1diD3ujeGjPgnNWnuyaGlCIN6hDdXsdJCVDfctRJjipy1I8chQXCE5TKsh8pqm04Rl_-_I_6Au4cauA</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Nguyen, Chu Luan</creator><creator>Liu, Yi Hui Angella</creator><creator>Lata, Tahmina</creator><creator>Easwaralingam, Neshanth</creator><creator>Seah, Jue Li</creator><creator>Chan, Carina</creator><creator>Cao, Felicia</creator><creator>Azimi, Farhad</creator><creator>Mak, Cindy</creator><creator>Pulitano, Carlo</creator><creator>Warrier, Sanjay Kumar</creator><general>Springer Berlin Heidelberg</general><scope>C6C</scope><scope>AAYXX</scope><scope>CITATION</scope><orcidid>https://orcid.org/0000-0002-6154-9369</orcidid></search><sort><creationdate>20221001</creationdate><title>Utility of indocyanine green angiography in delaying breast reconstruction postmastectomy</title><author>Nguyen, Chu Luan ; Liu, Yi Hui Angella ; Lata, Tahmina ; Easwaralingam, Neshanth ; Seah, Jue Li ; Chan, Carina ; Cao, Felicia ; Azimi, Farhad ; Mak, Cindy ; Pulitano, Carlo ; Warrier, Sanjay Kumar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-75a8dac1187b96f3a3e6e7a55d5edda10e68903e1d0d4f8ed7382390aba9dccf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Paper</topic><topic>Plastic Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, Chu Luan</creatorcontrib><creatorcontrib>Liu, Yi Hui Angella</creatorcontrib><creatorcontrib>Lata, Tahmina</creatorcontrib><creatorcontrib>Easwaralingam, Neshanth</creatorcontrib><creatorcontrib>Seah, Jue Li</creatorcontrib><creatorcontrib>Chan, Carina</creatorcontrib><creatorcontrib>Cao, Felicia</creatorcontrib><creatorcontrib>Azimi, Farhad</creatorcontrib><creatorcontrib>Mak, Cindy</creatorcontrib><creatorcontrib>Pulitano, Carlo</creatorcontrib><creatorcontrib>Warrier, Sanjay Kumar</creatorcontrib><collection>SpringerOpen</collection><collection>CrossRef</collection><jtitle>European journal of plastic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, Chu Luan</au><au>Liu, Yi Hui Angella</au><au>Lata, Tahmina</au><au>Easwaralingam, Neshanth</au><au>Seah, Jue Li</au><au>Chan, Carina</au><au>Cao, Felicia</au><au>Azimi, Farhad</au><au>Mak, Cindy</au><au>Pulitano, Carlo</au><au>Warrier, Sanjay Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Utility of indocyanine green angiography in delaying breast reconstruction postmastectomy</atitle><jtitle>European journal of plastic surgery</jtitle><stitle>Eur J Plast Surg</stitle><date>2022-10-01</date><risdate>2022</risdate><volume>45</volume><issue>5</issue><spage>755</spage><epage>761</epage><pages>755-761</pages><issn>1435-0130</issn><eissn>1435-0130</eissn><abstract>Background
Perfusion mapping with indocyanine green angiography (ICGA) in breast reconstruction can change intraoperative plans and reduce the risk of flap necrosis. We evaluated the utility of ICGA in the decision to delay reconstruction postmastectomy and its predictive power for necrosis.
Methods
Single-institution retrospective study of implant-based breast reconstructions following mastectomy using ICGA from 2015 to 2021. A decision was made to proceed with immediate reconstruction or delay reconstruction based on clinical assessment and perfusion analysis. Incidence of complications in the immediate and delayed cohorts were assessed. Intraoperative ICGA perfusion values were correlated with postoperative outcomes to calculate diagnostic accuracy.
Results
Three hundred twenty breast reconstructions were performed. Two hundred fifty-nine of these underwent immediate reconstruction, while 61 underwent delayed reconstruction due to poor perfusion. Median time between mastectomy and delayed reconstruction was 7.3 days (range, 4–21 days). All 8 cases (3.1%) of necrosis were in the immediate cohort. Cases of necrosis had significantly lower intraoperative ICGA perfusion values compared to cases without necrosis (absolute values 13.1 versus 27.1 units,
p
= 0.017). Increasing our ICGA cut-off score for necrosis from 14 to 22 units would have increased sensitivity from 63 to 100% but reduced specificity from 70 to 48%.
Conclusions
Delayed breast reconstruction due to poor perfusion on ICGA resulted in no cases of necrosis. A higher ICGA cut-off score for predicting necrosis is more sensitive but less specific. ICGA is useful as a supplement rather than a substitute for clinical assessment in flap perfusion evaluation.
Level of Evidence Level III, Risk / Diagnostic Study.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00238-022-01944-3</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-6154-9369</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Medicine Medicine & Public Health Original Paper Plastic Surgery |
title | Utility of indocyanine green angiography in delaying breast reconstruction postmastectomy |
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