Evidence for metabolic origin of absorptive hypercalciuria Type II

The objective of this retrospective data analysis was to test the hypothesis that absorptive hypercalciuria Type II (AH-II) is a less severe variant of absorptive hypercalciuria Type I (AH-I), a common cause of calcareous stones. 24-h urinary calcium obtained on constant metabolic diets was retrieve...

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Bibliographic Details
Published in:Urolithiasis 2011-04, Vol.39 (2), p.147-152
Main Authors: Pak, Charles Y. C., Pearle, Margaret S., Sakhaee, Khashayar
Format: Article
Language:English
Subjects:
Calcium, Dietary - administration & dosage
Calcium, Dietary - pharmacokinetics
Female
Humans
Hypercalciuria - classification
Hypercalciuria - diagnosis
Hypercalciuria - etiology
Hypercalciuria - metabolism
Intestinal Absorption
Male
Medical Biochemistry
Medicine
Medicine & Public Health
Nephrology
Original Paper
Retrospective Studies
Syndrome
Urology
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Summary:The objective of this retrospective data analysis was to test the hypothesis that absorptive hypercalciuria Type II (AH-II) is a less severe variant of absorptive hypercalciuria Type I (AH-I), a common cause of calcareous stones. 24-h urinary calcium obtained on constant metabolic diets was retrieved from several data sources, including those of the authors and another group. On a low calcium diet (10 mmol calcium), 35 patients with AH-II were compared with 70 non-stone formers (NSF) and 76 patients with AH-I. On a high calcium diet (25 mmol calcium/day), 10 patients with AH-II were compared with 35 NSF and 32 with AH-I. On a low calcium diet for all participants, 24-h urinary calcium in AH-II (4.13 ± 0.63 mmol/day) was significantly higher than in NSF (3.06 ± 1.17 mmol/day), but significantly lower than in AH-I (6.11 ± 1.14 mmol/day) ( p  
ISSN:0300-5623
2194-7228
1434-0879
2194-7236
DOI:10.1007/s00240-010-0315-0