Iodixanol pharmacokinetics in children

The objective of this report was to study the elimination pharmacokinetics of iodixanol in children. Iodixanol (Visipaque, Nycomed Inc., Wayne, PA, USA) is a new iso-osmolar iodinated radiocontrast agent. We hypothesized that elimination of this agent would be dependent on age-related differences in...

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Bibliographic Details
Published in:Pediatric cardiology 2001-05, Vol.22 (3), p.223-227
Main Authors: Johnson , Jr, W H, Lloyd, T R, Victorica, B E, Zales, V R, Epstein, M L, Leff, R D, Ardinger , Jr, R H, Slovis, T L, Johnson, J A, Marsters, P A
Format: Article
Language:English
Subjects:
Age Factors
Angiocardiography
Child
Child, Preschool
Contrast Media - administration & dosage
Contrast Media - pharmacokinetics
Drug Interactions
Female
Humans
Infant
Infant, Newborn
Linear Models
Male
Metabolic Clearance Rate
Tomography, X-Ray Computed
Triiodobenzoic Acids - administration & dosage
Triiodobenzoic Acids - pharmacokinetics
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Summary:The objective of this report was to study the elimination pharmacokinetics of iodixanol in children. Iodixanol (Visipaque, Nycomed Inc., Wayne, PA, USA) is a new iso-osmolar iodinated radiocontrast agent. We hypothesized that elimination of this agent would be dependent on age-related differences in renal clearance. Seven centers enrolled 43 patients. Cardiac catheterization was performed in 41 patients and cranial computed tomography in 2. Patients were entered into 5 age groups: newborn to
ISSN:0172-0643
1432-1971
DOI:10.1007/s002460010208