Cardiac Malformations Are Increased in Infants of Mothers with Epilepsy

We aimed to ascertain the prevalence of cardiac malformation (CM) and its association with antenatal exposure to an antiepileptic drug (AED) in infants of mothers with epilepsy (IMEs). Women with epilepsy (WWE) are enrolled in Kerala Registry of Epilepsy and Pregnancy (KREP) in the prepregnancy or e...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric cardiology 2008-05, Vol.29 (3), p.604-608
Main Authors: Thomas, S. V., Ajaykumar, B., Sindhu, K., Francis, E., Namboodiri, N., Sivasankaran, S., Tharakan, J. A., Sarma, P. S.
Format: Article
Language:English
Subjects:
Adult
Anticonvulsants - adverse effects
Cardiac Surgery
Cardiology
Epilepsy - drug therapy
Female
Heart Defects, Congenital - chemically induced
Heart Defects, Congenital - epidemiology
Humans
Infant, Newborn
Male
Medicine
Medicine & Public Health
Original Article
Pregnancy
Prenatal Exposure Delayed Effects
Prevalence
Prospective Studies
Vascular Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We aimed to ascertain the prevalence of cardiac malformation (CM) and its association with antenatal exposure to an antiepileptic drug (AED) in infants of mothers with epilepsy (IMEs). Women with epilepsy (WWE) are enrolled in Kerala Registry of Epilepsy and Pregnancy (KREP) in the prepregnancy or early pregnancy period and are followed up with a standard protocol until the IMEs are 6 years old. At 3 months postpartum, a cardiologist, blinded to the AED exposure, carried out a clinical examination and echocardiography on all live-born babies. Patent foramen ovale (PFO) and interatrial septal defects of 
ISSN:0172-0643
1432-1971
DOI:10.1007/s00246-007-9161-4