Brown adipose tissue 18F-FDG uptake in pediatric PET/CT imaging

Positron emission tomography (PET) using [F-18]2-fluoro-2-deoxyglucose (FDG) fused with CT ( 18 F-FDG PET/CT) has been widely adopted in oncological imaging. However, it is known that benign lesions and other metabolically active tissues, such as brown adipose tissue (BAT), can accumulate 18 F-FDG,...

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Bibliographic Details
Published in:Pediatric radiology 2011-06, Vol.41 (6), p.759-768
Main Authors: Hong, Terence S., Shammas, Amer, Charron, Martin, Zukotynski, Katherine A., Drubach, Laura A., Lim, Ruth
Format: Article
Language:English
Subjects:
Adipose Tissue, Brown - diagnostic imaging
Adipose Tissue, Brown - metabolism
Adolescent
Child
Child, Preschool
Female
Fluorodeoxyglucose F18 - pharmacokinetics
Humans
Imaging
Infant
Male
Medicine
Medicine & Public Health
Metabolic Clearance Rate
Neuroradiology
Nuclear Medicine
Oncology
Organ Specificity
Pediatrics
Pictorial Essay
Positron-Emission Tomography - methods
Radiology
Radiopharmaceuticals - pharmacokinetics
Subtraction Technique
Tissue Distribution
Tomography, X-Ray Computed - methods
Ultrasound
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Summary:Positron emission tomography (PET) using [F-18]2-fluoro-2-deoxyglucose (FDG) fused with CT ( 18 F-FDG PET/CT) has been widely adopted in oncological imaging. However, it is known that benign lesions and other metabolically active tissues, such as brown adipose tissue (BAT), can accumulate 18 F-FDG, potentially resulting in false-positive interpretation. Previous studies have reported that 18 F-FDG uptake in BAT is more common in children than in adults. We illustrate BAT FDG uptake in various anatomical locations in children and adolescents. We also review what is known about the effects of patient-related physical attributes and environmental temperatures on BAT FDG uptake, and discuss methods used to reduce BAT FDG uptake on 18 F-FDG PET.
ISSN:0301-0449
1432-1998
DOI:10.1007/s00247-010-1925-y