Preoperative risk stratification using metabolic parameters of 18F-FDG PET/CT in patients with endometrial cancer

• Published in: European journal of nuclear medicine and molecular imaging 2015-07, Vol.42 (8), p.1268-1275
• Main Authors: Kitajima, Kazuhiro, Suenaga, Yuko, Ueno, Yoshiko, Maeda, Tetsuo, Ebina, Yasuhiko, Yamada, Hideto, Okunaga, Takashi, Kubo, Kazuhiro, Sofue, Keitarou, Kanda, Tomonori, Tamaki, Yukihisa, Sugimura, Kazuro
• Format: Article
• Language: English
• Subjects: Cardiology; Imaging; Medicine; Medicine & Public Health; Nuclear Medicine; Oncology; Original Article; Orthopedics; Radiology
• ISSN: 1619-7070; 1619-7089
• DOI: 10.1007/s00259-015-3037-2

Purpose To evaluate the usefulness of metabolic parameters obtained by 18 F-FDG PET/CT for preoperative stratification of high-risk and low-risk endometrial carcinomas. Methods Preoperative 18 F-FDG PET/CT was performed in 56 women with endometrial cancer. Maximum standardized uptake values (SUVmax), metabolic tumour volume (MTV) and total lesion glycolysis (TLG) of primary tumours were compared with clinicopathological features of surgical specimens. Diagnostic performance in terms of differentiation of low-risk disease (endometrioid histology, histological grade 1 or 2, invasion of less than half of the myometrium, and FIGO stage I) from high-risk disease was assessed. Results MTV and TLG were significantly higher in patients with higher histological grade ( p  = 0.0026 and p  = 0.034), larger tumour size ( p  = 0.002 and p  = 0.0017), lymphovascular space involvement (LVSI; p  = 0.012 and p  = 0.0051), myometrial invasion ( p  = 0.027 and p  = 0.031), cervical stromal invasion ( p  = 0.023 and p  = 0.014), ovarian metastasis ( p  = 0.00022 and p  = 0.00034), lymph node metastasis ( p