Copper–strontium hydroxyapatite/chitosan/polyvinyl alcohol/gelatin electrospun composite and its biological studies for orthopedic applications

Sol–gel method is utilized to prepare copper and strontium substituted hydroxyapatite (Cu–Sr–HAP). Electrospinning method is utilized to prepare chitosan (CS)/polyvinyl alcohol (PVA)/gelatin (Gel) and (Cu–Sr–HAP)/CS/PVA/Gel composites. The structure of the electrospun composites is characterized by...

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Bibliographic Details
Published in:Polymer bulletin (Berlin, Germany) Germany), 2024, Vol.81 (2), p.1193-1210
Main Authors: Valarmathi, Narayanan, Sabareeswari, Kalidas, Sumathi, Shanmugam
Format: Article
Language:English
Subjects:
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Organic Chemistry
Original Paper
Physical Chemistry
Polymer Sciences
Soft and Granular Matter
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Summary:Sol–gel method is utilized to prepare copper and strontium substituted hydroxyapatite (Cu–Sr–HAP). Electrospinning method is utilized to prepare chitosan (CS)/polyvinyl alcohol (PVA)/gelatin (Gel) and (Cu–Sr–HAP)/CS/PVA/Gel composites. The structure of the electrospun composites is characterized by various analytical techniques such as X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), and scanning electron microscopy and energy-dispersive X-ray spectroscopy (SEM-EDAX). (Cu–Sr–HAP)/CS/PVA/Gel electrospun composite showed excellent antimicrobial activity compared to pure CS/PVA/Gel composite. In vitro biomineralization assay confirmed the formation of an apatite layer on the surface of (Cu–Sr–HAP)/CS/PVA/Gel composite. 65.45 ± 1.27 MPa tensile strength and 121.28 ± 1.76% elongation at break value are observed for the Cu–Sr–HAP)/CS/PVA/Gel electrospun composite.
ISSN:0170-0839
1436-2449
DOI:10.1007/s00289-023-04761-1