The efficacy of silver-embedded polypropylene-grafted polyethylene glycol-coated ventricular catheters on prevention of shunt catheter infection in rats

Purpose Catheter-related infection is a major complication of ventriculoperitoneal shunt in children. The aim of this study is to determine inflammatory response and the efficacy of polypropylene-grafted polyethylene glycol (PP-g-PEG) copolymer and silver nanoparticle-embedded PP-g-PEG (Ag-PP-g-PEG)...

Full description

Saved in:
Bibliographic Details
Published in:Child's nervous system 2012-06, Vol.28 (6), p.839-846
Main Authors: Hazer, Derya Burcu, Mut, Melike, Dinçer, Nazmiye, Saribas, Zeynep, Hazer, Baki, Özgen, Tunçalp
Format: Article
Language:English
Subjects:
Animals
Catheter-Related Infections - prevention & control
Catheters, Indwelling - adverse effects
Catheters, Indwelling - microbiology
Disease Models, Animal
Medicine
Medicine & Public Health
Nanoparticles
Neurosciences
Neurosurgery
Original Paper
Polyethylene Glycols - pharmacology
Polypropylenes - pharmacology
Rats
Rats, Wistar
Silver - pharmacology
Ventriculoperitoneal Shunt - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose Catheter-related infection is a major complication of ventriculoperitoneal shunt in children. The aim of this study is to determine inflammatory response and the efficacy of polypropylene-grafted polyethylene glycol (PP-g-PEG) copolymer and silver nanoparticle-embedded PP-g-PEG (Ag-PP-g-PEG) polymer-coated ventricular catheters on the prevention of catheter-related infections on a new experimental model of ventriculoperitoneal shunt in rats. Methods Thirty six Wistar albino rats were divided into six groups: group 1, unprocessed sterile silicone catheter-embedded group; group 2, sterile PP-g-PEG-coated catheter group; group 3, sterile Ag-PP-g-PEG-coated catheter group; group 4, infected unprocessed catheter group; group 5, infected PP-g-PEG-coated catheter group; and group 6, infected Ag-PP-g-PEG-coated catheter group, respectively. In all groups, 1-cm piece of designated catheters were placed into the cisterna magna. In groups 4, 5, and 6, all rats were infected with 0.2 mL of 10 × 10 6 colony forming units (CFU)/mL Staphylococcus epidermidis colonies before the catheters were placed. Thirty days after implantation, bacterial colonization in cerebrospinal fluid and on catheter pieces with inflammatory reaction in the brain parenchyma was analyzed quantitatively. Results Sterile and infected Ag-PP-g-PEG-covered groups revealed significantly lower bacteria colony count on the catheter surface (ANOVA, 0 ± 0, p  
ISSN:0256-7040
1433-0350
DOI:10.1007/s00381-012-1729-5