Loading…

Distinct survival and clinical profile of infantile glioblastoma: insights from a national database

Background The diagnosis of glioblastoma (GBM) in infants aged ≤ 1 year is extremely rare, and its comparability to the more common adult diagnosis is underexplored. Correspondingly, the objective of this study was to interrogate a national cancer database to elucidate the typical survival and clini...

Full description

Saved in:
Bibliographic Details
Published in:Child's nervous system 2022, Vol.38 (1), p.85-94
Main Authors: Lu, Victor M., Eichberg, Daniel G., Luther, Evan M., Shah, Ashish H., Daniels, David J., Maher, Ossama M., Niazi, Toba N.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background The diagnosis of glioblastoma (GBM) in infants aged ≤ 1 year is extremely rare, and its comparability to the more common adult diagnosis is underexplored. Correspondingly, the objective of this study was to interrogate a national cancer database to elucidate the typical survival and clinical profile of this demographic. Methods All GBM patients aged ≤ 1 year in the U.S. National Cancer Database (NCDB) between 2005 and 2016 were retrospectively reviewed. Data were summarized, and overall survival (OS) was modeled using Kaplan–Meier and Cox regression analyses. Results A total of 86 patients satisfied criteria for entry into study, making up 0.08% of all GBM diagnoses in the database. There were 32 (37%) females and 54 (63%) males. Irrespective of treatment, median OS was 67.3 months (95% CI, 46–91), which was distinct from all other ages and pediatric age groups. There were 74 (86%) treated by surgery, 51 (59%) treated by chemotherapy, and 17 (20%) treated by radiation therapy. Multivariable analysis demonstrated that Hispanic status ( HR  = 3.41, P  = 0.02) and the presence of comorbidity ( HR  = 3.24, P  = 0.01) independently predicted shorter OS, whereas treatment with chemotherapy ( HR  = 0.18, P  
ISSN:0256-7040
1433-0350
DOI:10.1007/s00381-021-05386-3