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Distinct survival and clinical profile of infantile glioblastoma: insights from a national database
Background The diagnosis of glioblastoma (GBM) in infants aged ≤ 1 year is extremely rare, and its comparability to the more common adult diagnosis is underexplored. Correspondingly, the objective of this study was to interrogate a national cancer database to elucidate the typical survival and clini...
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| Published in: | Child's nervous system 2022, Vol.38 (1), p.85-94 |
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| creator | Lu, Victor M. Eichberg, Daniel G. Luther, Evan M. Shah, Ashish H. Daniels, David J. Maher, Ossama M. Niazi, Toba N. |
| description | Background
The diagnosis of glioblastoma (GBM) in infants aged ≤ 1 year is extremely rare, and its comparability to the more common adult diagnosis is underexplored. Correspondingly, the objective of this study was to interrogate a national cancer database to elucidate the typical survival and clinical profile of this demographic.
Methods
All GBM patients aged ≤ 1 year in the U.S. National Cancer Database (NCDB) between 2005 and 2016 were retrospectively reviewed. Data were summarized, and overall survival (OS) was modeled using Kaplan–Meier and Cox regression analyses.
Results
A total of 86 patients satisfied criteria for entry into study, making up 0.08% of all GBM diagnoses in the database. There were 32 (37%) females and 54 (63%) males. Irrespective of treatment, median OS was 67.3 months (95% CI, 46–91), which was distinct from all other ages and pediatric age groups. There were 74 (86%) treated by surgery, 51 (59%) treated by chemotherapy, and 17 (20%) treated by radiation therapy. Multivariable analysis demonstrated that Hispanic status (
HR
= 3.41,
P
= 0.02) and the presence of comorbidity (
HR
= 3.24,
P
= 0.01) independently predicted shorter OS, whereas treatment with chemotherapy (
HR
= 0.18,
P
|
| doi_str_mv | 10.1007/s00381-021-05386-3 |
| format | article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1007_s00381_021_05386_3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>34643775</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-31a5998ffb6df46c85965c885310e5afced2b3fa9e60f8919a0bc607761b90cc3</originalsourceid><addsrcrecordid>eNp9kE1OwzAQhS0EoqVwARYoFwiM49ix2aHyK1ViA2vLceziKnEq263E7XEJsGQxGs3Me0-aD6FLDNcYoLmJAITjEqpclHBWkiM0xzUhJRAKx2gOFWVlAzXM0FmMGwBMeSVO0YzUrCZNQ-dI37uYnNepiLuwd3vVF8p3he6ddzoP2zBa15titIXzVvl0GNa9G9texTQO6jbvo1t_pFjYMA6FKrxKbvTZ26mkWhXNOTqxqo_m4qcv0Pvjw9vyuVy9Pr0s71alJnWTSoIVFYJb27LO1kxzKhjVnFOCwVBltemqllglDAPLBRYKWs2gaRhuBWhNFqiacnUYYwzGym1wgwqfEoM8EJMTMZmJyW9ikmTT1WTa7trBdH-WX0RZQCZBzCe_NkFuxl3I_8X_Yr8AQvp4fg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Distinct survival and clinical profile of infantile glioblastoma: insights from a national database</title><source>Springer Link</source><creator>Lu, Victor M. ; Eichberg, Daniel G. ; Luther, Evan M. ; Shah, Ashish H. ; Daniels, David J. ; Maher, Ossama M. ; Niazi, Toba N.</creator><creatorcontrib>Lu, Victor M. ; Eichberg, Daniel G. ; Luther, Evan M. ; Shah, Ashish H. ; Daniels, David J. ; Maher, Ossama M. ; Niazi, Toba N.</creatorcontrib><description>Background
The diagnosis of glioblastoma (GBM) in infants aged ≤ 1 year is extremely rare, and its comparability to the more common adult diagnosis is underexplored. Correspondingly, the objective of this study was to interrogate a national cancer database to elucidate the typical survival and clinical profile of this demographic.
Methods
All GBM patients aged ≤ 1 year in the U.S. National Cancer Database (NCDB) between 2005 and 2016 were retrospectively reviewed. Data were summarized, and overall survival (OS) was modeled using Kaplan–Meier and Cox regression analyses.
Results
A total of 86 patients satisfied criteria for entry into study, making up 0.08% of all GBM diagnoses in the database. There were 32 (37%) females and 54 (63%) males. Irrespective of treatment, median OS was 67.3 months (95% CI, 46–91), which was distinct from all other ages and pediatric age groups. There were 74 (86%) treated by surgery, 51 (59%) treated by chemotherapy, and 17 (20%) treated by radiation therapy. Multivariable analysis demonstrated that Hispanic status (
HR
= 3.41,
P
= 0.02) and the presence of comorbidity (
HR
= 3.24,
P
= 0.01) independently predicted shorter OS, whereas treatment with chemotherapy (
HR
= 0.18,
P
< 0.01) independently predicted longer OS. Neither extent of surgery nor radiation therapy demonstrated independent statistical significance.
Conclusion
Infantile GBM should be viewed as a distinct GBM entity with a longer OS than other pediatric and adult patients. Chemotherapy is a statistically significant component in the treatment of this demographic, and the value of surgical treatment is likely universal. Future studies into understanding the biological and genetic profile of infantile GBM are needed to advance both pediatric and adult fields.</description><identifier>ISSN: 0256-7040</identifier><identifier>EISSN: 1433-0350</identifier><identifier>DOI: 10.1007/s00381-021-05386-3</identifier><identifier>PMID: 34643775</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Brain Neoplasms - drug therapy ; Child ; Databases, Factual ; Female ; Glioblastoma ; Humans ; Infant ; Kaplan-Meier Estimate ; Male ; Medicine ; Medicine & Public Health ; Neurosciences ; Neurosurgery ; Original Article ; Prognosis ; Retrospective Studies</subject><ispartof>Child's nervous system, 2022, Vol.38 (1), p.85-94</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2021</rights><rights>2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-31a5998ffb6df46c85965c885310e5afced2b3fa9e60f8919a0bc607761b90cc3</citedby><cites>FETCH-LOGICAL-c347t-31a5998ffb6df46c85965c885310e5afced2b3fa9e60f8919a0bc607761b90cc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34643775$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Victor M.</creatorcontrib><creatorcontrib>Eichberg, Daniel G.</creatorcontrib><creatorcontrib>Luther, Evan M.</creatorcontrib><creatorcontrib>Shah, Ashish H.</creatorcontrib><creatorcontrib>Daniels, David J.</creatorcontrib><creatorcontrib>Maher, Ossama M.</creatorcontrib><creatorcontrib>Niazi, Toba N.</creatorcontrib><title>Distinct survival and clinical profile of infantile glioblastoma: insights from a national database</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><addtitle>Childs Nerv Syst</addtitle><description>Background
The diagnosis of glioblastoma (GBM) in infants aged ≤ 1 year is extremely rare, and its comparability to the more common adult diagnosis is underexplored. Correspondingly, the objective of this study was to interrogate a national cancer database to elucidate the typical survival and clinical profile of this demographic.
Methods
All GBM patients aged ≤ 1 year in the U.S. National Cancer Database (NCDB) between 2005 and 2016 were retrospectively reviewed. Data were summarized, and overall survival (OS) was modeled using Kaplan–Meier and Cox regression analyses.
Results
A total of 86 patients satisfied criteria for entry into study, making up 0.08% of all GBM diagnoses in the database. There were 32 (37%) females and 54 (63%) males. Irrespective of treatment, median OS was 67.3 months (95% CI, 46–91), which was distinct from all other ages and pediatric age groups. There were 74 (86%) treated by surgery, 51 (59%) treated by chemotherapy, and 17 (20%) treated by radiation therapy. Multivariable analysis demonstrated that Hispanic status (
HR
= 3.41,
P
= 0.02) and the presence of comorbidity (
HR
= 3.24,
P
= 0.01) independently predicted shorter OS, whereas treatment with chemotherapy (
HR
= 0.18,
P
< 0.01) independently predicted longer OS. Neither extent of surgery nor radiation therapy demonstrated independent statistical significance.
Conclusion
Infantile GBM should be viewed as a distinct GBM entity with a longer OS than other pediatric and adult patients. Chemotherapy is a statistically significant component in the treatment of this demographic, and the value of surgical treatment is likely universal. Future studies into understanding the biological and genetic profile of infantile GBM are needed to advance both pediatric and adult fields.</description><subject>Adult</subject><subject>Aged</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Child</subject><subject>Databases, Factual</subject><subject>Female</subject><subject>Glioblastoma</subject><subject>Humans</subject><subject>Infant</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosciences</subject><subject>Neurosurgery</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kE1OwzAQhS0EoqVwARYoFwiM49ix2aHyK1ViA2vLceziKnEq263E7XEJsGQxGs3Me0-aD6FLDNcYoLmJAITjEqpclHBWkiM0xzUhJRAKx2gOFWVlAzXM0FmMGwBMeSVO0YzUrCZNQ-dI37uYnNepiLuwd3vVF8p3he6ddzoP2zBa15titIXzVvl0GNa9G9texTQO6jbvo1t_pFjYMA6FKrxKbvTZ26mkWhXNOTqxqo_m4qcv0Pvjw9vyuVy9Pr0s71alJnWTSoIVFYJb27LO1kxzKhjVnFOCwVBltemqllglDAPLBRYKWs2gaRhuBWhNFqiacnUYYwzGym1wgwqfEoM8EJMTMZmJyW9ikmTT1WTa7trBdH-WX0RZQCZBzCe_NkFuxl3I_8X_Yr8AQvp4fg</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Lu, Victor M.</creator><creator>Eichberg, Daniel G.</creator><creator>Luther, Evan M.</creator><creator>Shah, Ashish H.</creator><creator>Daniels, David J.</creator><creator>Maher, Ossama M.</creator><creator>Niazi, Toba N.</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>2022</creationdate><title>Distinct survival and clinical profile of infantile glioblastoma: insights from a national database</title><author>Lu, Victor M. ; Eichberg, Daniel G. ; Luther, Evan M. ; Shah, Ashish H. ; Daniels, David J. ; Maher, Ossama M. ; Niazi, Toba N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-31a5998ffb6df46c85965c885310e5afced2b3fa9e60f8919a0bc607761b90cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Brain Neoplasms - drug therapy</topic><topic>Child</topic><topic>Databases, Factual</topic><topic>Female</topic><topic>Glioblastoma</topic><topic>Humans</topic><topic>Infant</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosciences</topic><topic>Neurosurgery</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Victor M.</creatorcontrib><creatorcontrib>Eichberg, Daniel G.</creatorcontrib><creatorcontrib>Luther, Evan M.</creatorcontrib><creatorcontrib>Shah, Ashish H.</creatorcontrib><creatorcontrib>Daniels, David J.</creatorcontrib><creatorcontrib>Maher, Ossama M.</creatorcontrib><creatorcontrib>Niazi, Toba N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Victor M.</au><au>Eichberg, Daniel G.</au><au>Luther, Evan M.</au><au>Shah, Ashish H.</au><au>Daniels, David J.</au><au>Maher, Ossama M.</au><au>Niazi, Toba N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinct survival and clinical profile of infantile glioblastoma: insights from a national database</atitle><jtitle>Child's nervous system</jtitle><stitle>Childs Nerv Syst</stitle><addtitle>Childs Nerv Syst</addtitle><date>2022</date><risdate>2022</risdate><volume>38</volume><issue>1</issue><spage>85</spage><epage>94</epage><pages>85-94</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>Background
The diagnosis of glioblastoma (GBM) in infants aged ≤ 1 year is extremely rare, and its comparability to the more common adult diagnosis is underexplored. Correspondingly, the objective of this study was to interrogate a national cancer database to elucidate the typical survival and clinical profile of this demographic.
Methods
All GBM patients aged ≤ 1 year in the U.S. National Cancer Database (NCDB) between 2005 and 2016 were retrospectively reviewed. Data were summarized, and overall survival (OS) was modeled using Kaplan–Meier and Cox regression analyses.
Results
A total of 86 patients satisfied criteria for entry into study, making up 0.08% of all GBM diagnoses in the database. There were 32 (37%) females and 54 (63%) males. Irrespective of treatment, median OS was 67.3 months (95% CI, 46–91), which was distinct from all other ages and pediatric age groups. There were 74 (86%) treated by surgery, 51 (59%) treated by chemotherapy, and 17 (20%) treated by radiation therapy. Multivariable analysis demonstrated that Hispanic status (
HR
= 3.41,
P
= 0.02) and the presence of comorbidity (
HR
= 3.24,
P
= 0.01) independently predicted shorter OS, whereas treatment with chemotherapy (
HR
= 0.18,
P
< 0.01) independently predicted longer OS. Neither extent of surgery nor radiation therapy demonstrated independent statistical significance.
Conclusion
Infantile GBM should be viewed as a distinct GBM entity with a longer OS than other pediatric and adult patients. Chemotherapy is a statistically significant component in the treatment of this demographic, and the value of surgical treatment is likely universal. Future studies into understanding the biological and genetic profile of infantile GBM are needed to advance both pediatric and adult fields.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34643775</pmid><doi>10.1007/s00381-021-05386-3</doi><tpages>10</tpages></addata></record> |
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| subjects | Adult Aged Brain Neoplasms - drug therapy Child Databases, Factual Female Glioblastoma Humans Infant Kaplan-Meier Estimate Male Medicine Medicine & Public Health Neurosciences Neurosurgery Original Article Prognosis Retrospective Studies |
| title | Distinct survival and clinical profile of infantile glioblastoma: insights from a national database |
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