Studies on the radioprotective potency of amifostine on salivary glands of rats during fractionated irradiation : Acute and late effects

The purpose of this study was to evaluate the radioprotective potential of amifostine on the salivary glands of rats with respect to the acute and late effects. The head and neck area of WAG/RijH rats was irradiated with (60)Co-gamma rays (60 Gy/30f for 6 weeks). Amifostine (250 mg/m(2) body surface...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2003, Vol.260 (1), p.42-47
Main Authors: SAGOWSKI, Christoph, WENZEL, Soeren, METTERNICH, Frank Uwe, KEHRL, Wolfgang
Format: Article
Language:English
Subjects:
Acute Disease
Amifostine - pharmacology
Amifostine - therapeutic use
Animals
Biological and medical sciences
Drug-Related Side Effects and Adverse Reactions
Male
Medical sciences
Non tumoral diseases
Otorhinolaryngology. Stomatology
Radiation Dosage
Radiation therapy and radiosensitizing agent
Radiation-Protective Agents - pharmacology
Radiation-Protective Agents - therapeutic use
Rats
Salivary Glands - drug effects
Salivary Glands - pathology
Treatment with physical agents
Treatment. General aspects
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
Xerostomia - drug therapy
Xerostomia - etiology
Xerostomia - pathology
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Summary:The purpose of this study was to evaluate the radioprotective potential of amifostine on the salivary glands of rats with respect to the acute and late effects. The head and neck area of WAG/RijH rats was irradiated with (60)Co-gamma rays (60 Gy/30f for 6 weeks). Amifostine (250 mg/m(2) body surface) or an equal volume of physiologic saline was applied intravenously 15 min before each irradiation. In the course of treatment the salivary glands were examined histopathologically. Body weight was measured sequentially during irradiation. A cytoprotective effect of amifostine on the acute toxicity of salivary glands could not be detected under fractionated irradiation. However, late effects such as fibrosis and necrosis of the glands 6 months after irradiation were less developed in the amifostine group. The weight loss of the amifostine-treated animals during fractioned irradiation was higher than in the irradiated group. Amifostine has a significant cytoprotective effect on the late toxicity of irradiated salivary glands. However, the acute toxicity of the glands during radiotherapy cannot be reduced.
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-002-0496-4