Gabapentin effectiveness on the sensation of subjective idiopathic tinnitus: a pilot study

This prospective, placebo-controlled, double-blind clinical trial evaluated the effectiveness of gabapentin in decreasing subjective features of idiopathic subjective tinnitus in the patients. Pure-tone audiograms, laboratory test and personal histories were used to exclude any particular etiology o...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2008-05, Vol.265 (5), p.525-530
Main Authors: Bakhshaee, Mehdi, Ghasemi, Mohammadmehdi, Azarpazhooh, Mahmoodreza, Khadivi, Ehsan, Rezaei, Saman, Shakeri, Mohammadtaghi, Tale, Mohammadreza
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Amines - administration & dosage
Amines - therapeutic use
Biological and medical sciences
Cyclohexanecarboxylic Acids - administration & dosage
Cyclohexanecarboxylic Acids - therapeutic use
Double-Blind Method
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Excitatory Amino Acid Antagonists - administration & dosage
Excitatory Amino Acid Antagonists - therapeutic use
Female
gamma-Aminobutyric Acid - administration & dosage
gamma-Aminobutyric Acid - therapeutic use
Head and Neck Surgery
Humans
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Neurosurgery
Non tumoral diseases
Otology
Otorhinolaryngology
Otorhinolaryngology. Stomatology
Pilot Projects
Tinnitus - drug therapy
Treatment Failure
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Description
Summary:This prospective, placebo-controlled, double-blind clinical trial evaluated the effectiveness of gabapentin in decreasing subjective features of idiopathic subjective tinnitus in the patients. Pure-tone audiograms, laboratory test and personal histories were used to exclude any particular etiology of tinnitus. Participants were restricted to those with moderate to severe idiopathic subjective tinnitus for at least 6 months. A total of 30 participants received gabapentin in a graduated ascending dose series extending over 4 weeks (peak dose of 900 mg/day). There was not a significant subjective improvement in tinnitus annoyance for the patients (37%) versus controls (42%). Comparison between the results before and after intervention for patients and controls according to subjective response, tinnitus questionnaire, tinnitus severity index and the loudness perception by the patient showed no significant differences ( P  > 0.05). There is insufficient evidence to support the effectiveness of gabapentin in the treatment of tinnitus up to now.
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-007-0504-9