Effects of polylactic acid film on middle ear mucosa and cochlear function in Guinea pigs

Our aim was to assess the effects of polylactic acid (PLA) on middle ear mucosa and cochlea, to be used as a film barrier for postoperative adhesion prevention in the middle ear. Twenty-one albino Guinea pigs were included in the study. A window was opened on both tympanic bulla and on one side PLA...

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Bibliographic Details
Published in:European archives of oto-rhino-laryngology 2015-05, Vol.272 (5), p.1091-1097
Main Authors: Ensari, Nuray, Tutar, Hakan, Ekinci, Ozgur, Ugur, Mehmet Birol, Bayazıt, Yıldırım A., Gokdogan, Cagil, Goksu, Nebil
Format: Article
Language:English
Subjects:
Animals
Cochlea - drug effects
Cochlea - physiopathology
Ear, Middle - drug effects
Ear, Middle - pathology
Ear, Middle - surgery
Evoked Potentials, Auditory, Brain Stem - drug effects
Guinea Pigs
Head and Neck Surgery
Lactic Acid - adverse effects
Lactic Acid - therapeutic use
Male
Medicine
Medicine & Public Health
Membranes, Artificial
Mucous Membrane - drug effects
Mucous Membrane - pathology
Neurosurgery
Otitis Media - surgery
Otology
Otorhinolaryngology
Polyesters
Polymers - adverse effects
Polymers - therapeutic use
Random Allocation
Tissue Adhesions - prevention & control
Treatment Outcome
Tympanic Membrane - drug effects
Tympanic Membrane - physiopathology
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Summary:Our aim was to assess the effects of polylactic acid (PLA) on middle ear mucosa and cochlea, to be used as a film barrier for postoperative adhesion prevention in the middle ear. Twenty-one albino Guinea pigs were included in the study. A window was opened on both tympanic bulla and on one side PLA material was placed in the middle ear and on the other side only fenestration was performed and used as a control. All Guinea pigs underwent evaluation of tympanic membranes microscopically; functional hearing was analyzed by auditory brainstem responses preoperatively, in the first and the sixth month. All Guinea pigs were killed on the sixth month for histopathologic evaluation of their temporal bones. There was no statistical difference between both groups regarding hearing thresholds, interpeak wave latencies preoperatively and on first and the sixth months postoperatively. Histopathological evaluation revealed no specific changes. There was a mild local inflammation both in the PLA implanted and control ears. PLA film barrier most likely has no toxic effects on Guinea pig middle ear and does not show any ototoxic side effects.
ISSN:0937-4477
1434-4726
DOI:10.1007/s00405-014-2904-y