Conversion to sirolimus of patients with chronic allograft nephropathy—a retrospective analysis of outcome and influencing factors

Purpose The purpose of this study was to analyse the outcome and its influencing factors in patients whose therapy was converted from calcineurin inhibitors (CNI) to sirolimus (SRL) due to chronic allograft nephropathy (CAN). Materials and methods Therapies of 78 patients (44 men) with CAN from thre...

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Bibliographic Details
Published in:Langenbeck's archives of surgery 2009-11, Vol.394 (6), p.1073-1078
Main Authors: Witzke, Oliver, Viklicky, Ondrej, Türk, Tobias R., Lutz, Jens, Wilde, Benjamin, Willenberg, Isabel, Vitko, Stefan, Heemann, Uwe
Format: Article
Language:English
Subjects:
Abdominal Surgery
Adult
Calcineurin Inhibitors
Cardiac Surgery
Cohort Studies
Cyclosporine - adverse effects
Female
General Surgery
Humans
Immunosuppressive Agents - therapeutic use
Kidney Diseases - diagnosis
Kidney Diseases - etiology
Kidney Diseases - therapy
Kidney Transplantation - adverse effects
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Retrospective Studies
Risk Factors
Sirolimus - therapeutic use
Thoracic Surgery
Traumatic Surgery
Treatment Outcome
Vascular Surgery
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Summary:Purpose The purpose of this study was to analyse the outcome and its influencing factors in patients whose therapy was converted from calcineurin inhibitors (CNI) to sirolimus (SRL) due to chronic allograft nephropathy (CAN). Materials and methods Therapies of 78 patients (44 men) with CAN from three European transplant centres were converted from CNI therapy to SRL and followed 24 months. Slopes for creatinine clearance before and after conversion were calculated. Influencing factors were analysed by a multivariance analysis. Results The slope of the creatinine clearance improved significantly (−0.90 vs. −0.34 ml min −1 month −1 ; p  
ISSN:1435-2443
1435-2451
DOI:10.1007/s00423-008-0435-y