Combined effects of caffeine and alcohol during pregnancy on bones in newborn rats

The combined effects of caffeine and alcohol on mineral contents of fetal mandibles and femurs were studied. Pregnant rats were divided into four groups: group 1, control; group 2, caffeine; group 3, alcohol; and group 4, caffeine-plus-alcohol. Alcohol (1.0 g ethanol/kg body weight) was intubated tw...

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Bibliographic Details
Published in:Research in experimental medicine 1996, Vol.196 (3), p.179
Main Authors: Case, T S, Saltzman, M J, Cheuk, J, Yazdani, M, Sadeghpour, A, Albrecht, D, Rossowska, M J, Nakamoto, T
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Caffeine - pharmacology
Calcium - analysis
Central Nervous System Depressants - pharmacology
Central Nervous System Stimulants - pharmacology
Drug Interactions
Ethanol - pharmacology
Female
Femur - chemistry
Femur - drug effects
Femur - embryology
Hydroxyproline - analysis
Magnesium - analysis
Mandible - chemistry
Mandible - drug effects
Mandible - embryology
Organ Size
Phosphorus - analysis
Pregnancy
Pregnancy, Animal - metabolism
Prenatal Exposure Delayed Effects
Rats
Rats, Sprague-Dawley
Zinc - analysis
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Summary:The combined effects of caffeine and alcohol on mineral contents of fetal mandibles and femurs were studied. Pregnant rats were divided into four groups: group 1, control; group 2, caffeine; group 3, alcohol; and group 4, caffeine-plus-alcohol. Alcohol (1.0 g ethanol/kg body weight) was intubated twice daily, beginning at day 9 of gestation. Caffeine (2 mg/100 g body weight) was given as a dietary supplement. Groups 1 and 2 were intubated with isocaloric sucrose solution. At birth, randomly selected pups were killed and the mandible and femur were removed and dried. Ca, P, Mg, Zn and hydroxyproline in these bones were measured. Notwithstanding the dams' intake of caffeine and alcohol administered separately, the present results suggest that the combination of caffeine and alcohol exhibited the most detrimental effects.
ISSN:0300-9130
DOI:10.1007/s004330050025