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Combined effects of caffeine and alcohol during pregnancy on bones in newborn rats
The combined effects of caffeine and alcohol on mineral contents of fetal mandibles and femurs were studied. Pregnant rats were divided into four groups: group 1, control; group 2, caffeine; group 3, alcohol; and group 4, caffeine-plus-alcohol. Alcohol (1.0 g ethanol/kg body weight) was intubated tw...
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| Published in: | Research in experimental medicine 1996, Vol.196 (3), p.179 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| container_issue | 3 |
| container_start_page | 179 |
| container_title | Research in experimental medicine |
| container_volume | 196 |
| creator | Case, T S Saltzman, M J Cheuk, J Yazdani, M Sadeghpour, A Albrecht, D Rossowska, M J Nakamoto, T |
| description | The combined effects of caffeine and alcohol on mineral contents of fetal mandibles and femurs were studied. Pregnant rats were divided into four groups: group 1, control; group 2, caffeine; group 3, alcohol; and group 4, caffeine-plus-alcohol. Alcohol (1.0 g ethanol/kg body weight) was intubated twice daily, beginning at day 9 of gestation. Caffeine (2 mg/100 g body weight) was given as a dietary supplement. Groups 1 and 2 were intubated with isocaloric sucrose solution. At birth, randomly selected pups were killed and the mandible and femur were removed and dried. Ca, P, Mg, Zn and hydroxyproline in these bones were measured. Notwithstanding the dams' intake of caffeine and alcohol administered separately, the present results suggest that the combination of caffeine and alcohol exhibited the most detrimental effects. |
| doi_str_mv | 10.1007/s004330050025 |
| format | article |
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Pregnant rats were divided into four groups: group 1, control; group 2, caffeine; group 3, alcohol; and group 4, caffeine-plus-alcohol. Alcohol (1.0 g ethanol/kg body weight) was intubated twice daily, beginning at day 9 of gestation. Caffeine (2 mg/100 g body weight) was given as a dietary supplement. Groups 1 and 2 were intubated with isocaloric sucrose solution. At birth, randomly selected pups were killed and the mandible and femur were removed and dried. Ca, P, Mg, Zn and hydroxyproline in these bones were measured. Notwithstanding the dams' intake of caffeine and alcohol administered separately, the present results suggest that the combination of caffeine and alcohol exhibited the most detrimental effects.</description><identifier>ISSN: 0300-9130</identifier><identifier>DOI: 10.1007/s004330050025</identifier><identifier>PMID: 8875704</identifier><language>eng</language><publisher>Germany</publisher><subject>Animals ; Animals, Newborn ; Caffeine - pharmacology ; Calcium - analysis ; Central Nervous System Depressants - pharmacology ; Central Nervous System Stimulants - pharmacology ; Drug Interactions ; Ethanol - pharmacology ; Female ; Femur - chemistry ; Femur - drug effects ; Femur - embryology ; Hydroxyproline - analysis ; Magnesium - analysis ; Mandible - chemistry ; Mandible - drug effects ; Mandible - embryology ; Organ Size ; Phosphorus - analysis ; Pregnancy ; Pregnancy, Animal - metabolism ; Prenatal Exposure Delayed Effects ; Rats ; Rats, Sprague-Dawley ; Zinc - analysis</subject><ispartof>Research in experimental medicine, 1996, Vol.196 (3), p.179</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8875704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Case, T S</creatorcontrib><creatorcontrib>Saltzman, M J</creatorcontrib><creatorcontrib>Cheuk, J</creatorcontrib><creatorcontrib>Yazdani, M</creatorcontrib><creatorcontrib>Sadeghpour, A</creatorcontrib><creatorcontrib>Albrecht, D</creatorcontrib><creatorcontrib>Rossowska, M J</creatorcontrib><creatorcontrib>Nakamoto, T</creatorcontrib><title>Combined effects of caffeine and alcohol during pregnancy on bones in newborn rats</title><title>Research in experimental medicine</title><addtitle>Res Exp Med (Berl)</addtitle><description>The combined effects of caffeine and alcohol on mineral contents of fetal mandibles and femurs were studied. Pregnant rats were divided into four groups: group 1, control; group 2, caffeine; group 3, alcohol; and group 4, caffeine-plus-alcohol. Alcohol (1.0 g ethanol/kg body weight) was intubated twice daily, beginning at day 9 of gestation. Caffeine (2 mg/100 g body weight) was given as a dietary supplement. Groups 1 and 2 were intubated with isocaloric sucrose solution. At birth, randomly selected pups were killed and the mandible and femur were removed and dried. Ca, P, Mg, Zn and hydroxyproline in these bones were measured. Notwithstanding the dams' intake of caffeine and alcohol administered separately, the present results suggest that the combination of caffeine and alcohol exhibited the most detrimental effects.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Caffeine - pharmacology</subject><subject>Calcium - analysis</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Drug Interactions</subject><subject>Ethanol - pharmacology</subject><subject>Female</subject><subject>Femur - chemistry</subject><subject>Femur - drug effects</subject><subject>Femur - embryology</subject><subject>Hydroxyproline - analysis</subject><subject>Magnesium - analysis</subject><subject>Mandible - chemistry</subject><subject>Mandible - drug effects</subject><subject>Mandible - embryology</subject><subject>Organ Size</subject><subject>Phosphorus - analysis</subject><subject>Pregnancy</subject><subject>Pregnancy, Animal - metabolism</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Zinc - analysis</subject><issn>0300-9130</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNpVkE1LAzEURbNQaq0uXQr5A6Mvn9MsZVArFATR9ZBkkjoykwzJFOm_N9IiuHqXx-HCPQjdELgjAPV9BuCMAQgAKs7QEkquFGFwgS5z_gIgtazJAi3W61rUwJforYmj6YPrsPPe2Tnj6LHVJZcn1qHDerDxMw6426c-7PCU3C7oYA84BmxicBn3AQf3bWIKOOk5X6Fzr4fsrk93hT6eHt-bTbV9fX5pHraVpZzPFe-85JI4ZZU2jjjgAoyUQAnXpDbUKA3CSgOCSFF2UGDMg5eqzFOeErZC1bHXpphzcr6dUj_qdGgJtL862n86Cn975Ke9GV33R59csB_V8lsr</recordid><startdate>1996</startdate><enddate>1996</enddate><creator>Case, T S</creator><creator>Saltzman, M J</creator><creator>Cheuk, J</creator><creator>Yazdani, M</creator><creator>Sadeghpour, A</creator><creator>Albrecht, D</creator><creator>Rossowska, M J</creator><creator>Nakamoto, T</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1996</creationdate><title>Combined effects of caffeine and alcohol during pregnancy on bones in newborn rats</title><author>Case, T S ; Saltzman, M J ; Cheuk, J ; Yazdani, M ; Sadeghpour, A ; Albrecht, D ; Rossowska, M J ; Nakamoto, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c244t-4df6461e9c9abe1e0450b660214a17b2b9a05c6b051653002033f0f690059f213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Caffeine - pharmacology</topic><topic>Calcium - analysis</topic><topic>Central Nervous System Depressants - pharmacology</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Drug Interactions</topic><topic>Ethanol - pharmacology</topic><topic>Female</topic><topic>Femur - chemistry</topic><topic>Femur - drug effects</topic><topic>Femur - embryology</topic><topic>Hydroxyproline - analysis</topic><topic>Magnesium - analysis</topic><topic>Mandible - chemistry</topic><topic>Mandible - drug effects</topic><topic>Mandible - embryology</topic><topic>Organ Size</topic><topic>Phosphorus - analysis</topic><topic>Pregnancy</topic><topic>Pregnancy, Animal - metabolism</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Zinc - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Case, T S</creatorcontrib><creatorcontrib>Saltzman, M J</creatorcontrib><creatorcontrib>Cheuk, J</creatorcontrib><creatorcontrib>Yazdani, M</creatorcontrib><creatorcontrib>Sadeghpour, A</creatorcontrib><creatorcontrib>Albrecht, D</creatorcontrib><creatorcontrib>Rossowska, M J</creatorcontrib><creatorcontrib>Nakamoto, T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Research in experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Case, T S</au><au>Saltzman, M J</au><au>Cheuk, J</au><au>Yazdani, M</au><au>Sadeghpour, A</au><au>Albrecht, D</au><au>Rossowska, M J</au><au>Nakamoto, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined effects of caffeine and alcohol during pregnancy on bones in newborn rats</atitle><jtitle>Research in experimental medicine</jtitle><addtitle>Res Exp Med (Berl)</addtitle><date>1996</date><risdate>1996</risdate><volume>196</volume><issue>3</issue><spage>179</spage><pages>179-</pages><issn>0300-9130</issn><abstract>The combined effects of caffeine and alcohol on mineral contents of fetal mandibles and femurs were studied. Pregnant rats were divided into four groups: group 1, control; group 2, caffeine; group 3, alcohol; and group 4, caffeine-plus-alcohol. Alcohol (1.0 g ethanol/kg body weight) was intubated twice daily, beginning at day 9 of gestation. Caffeine (2 mg/100 g body weight) was given as a dietary supplement. Groups 1 and 2 were intubated with isocaloric sucrose solution. At birth, randomly selected pups were killed and the mandible and femur were removed and dried. Ca, P, Mg, Zn and hydroxyproline in these bones were measured. Notwithstanding the dams' intake of caffeine and alcohol administered separately, the present results suggest that the combination of caffeine and alcohol exhibited the most detrimental effects.</abstract><cop>Germany</cop><pmid>8875704</pmid><doi>10.1007/s004330050025</doi></addata></record> |
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| identifier | ISSN: 0300-9130 |
| ispartof | Research in experimental medicine, 1996, Vol.196 (3), p.179 |
| issn | 0300-9130 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_s004330050025 |
| source | SpringerLink Online Journals Archive Complete |
| subjects | Animals Animals, Newborn Caffeine - pharmacology Calcium - analysis Central Nervous System Depressants - pharmacology Central Nervous System Stimulants - pharmacology Drug Interactions Ethanol - pharmacology Female Femur - chemistry Femur - drug effects Femur - embryology Hydroxyproline - analysis Magnesium - analysis Mandible - chemistry Mandible - drug effects Mandible - embryology Organ Size Phosphorus - analysis Pregnancy Pregnancy, Animal - metabolism Prenatal Exposure Delayed Effects Rats Rats, Sprague-Dawley Zinc - analysis |
| title | Combined effects of caffeine and alcohol during pregnancy on bones in newborn rats |
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