Efficacy of Emodepside plus Praziquantel Tablets (Profender® Tablets for Dogs) against Mature and Immature Infections with Toxocara canis and Toxascaris leonina in Dogs

• Published in: Parasitology research (1987) 2009-08, Vol.105 (1), p.1-8
• Main Authors: Altreuther, Gertraut, Schimmel, Annette, Schroeder, Iris, Bach, Thomas, Charles, Samuel, Kok, Dawid J, Kraemer, Friederike, Wolken, Sonja, Young, David, Krieger, Klemens J
• Format: Article
• Language: English
• Subjects: Administration, Oral; adults; adverse effects; Animals; Anthelmintics - administration & dosage; Anthelmintics - adverse effects; Anthelmintics - therapeutic use; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; body weight; Depsipeptides - administration & dosage; Depsipeptides - therapeutic use; Dog Diseases - drug therapy; Dog Diseases - parasitology; Dogs; Double-Blind Method; Feces - parasitology; Fundamental and applied biological sciences. Psychology; General aspects; General aspects and techniques. Study of several systematic groups. Models; Immunology; Invertebrates; Medical Microbiology; Microbiology; Parasite Egg Count; Placebos - administration & dosage; praziquantel; Praziquantel - administration & dosage; Praziquantel - therapeutic use; Tablets - administration & dosage; Tablets - therapeutic use; Toxascariasis - drug therapy; Toxascariasis - veterinary; Toxascaris - drug effects; Toxascaris leonina; Toxocara canis; Treatment Outcome
• ISSN: 0932-0113; 1432-1955
• DOI: 10.1007/s00436-009-1489-7

The efficacy of emodepside plus praziquantel tablets (Profender® tablets for dogs) against mature adult, immature adult and larval stages of Toxocara canis and Toxascaris leonina was evaluated in ten randomised, blinded and placebo-controlled dose confirmation studies in naturally or experimentally infected dogs. The tablets were used at the proposed minimum dose of 1 mg emodepside and 5 mg praziquantel per kg body weight. Efficacy was calculated based on worm counts after necropsy. Five studies demonstrated >99% efficacy against mature adult, >92% efficacy against immature adult, >98% efficacy against L4 and >94% efficacy against L3 larval stages of T. canis. Another five studies demonstrated >99% efficacy against mature and immature adult and >95% efficacy against L4 larval stages of T. leonina. No side effects of the treatment were observed. Emodepside plus praziquantel tablets thus provide a comprehensive new treatment option for ascarid infections in the dog.