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Efficacy of Emodepside plus Praziquantel Tablets (Profender® Tablets for Dogs) against Mature and Immature Infections with Toxocara canis and Toxascaris leonina in Dogs
The efficacy of emodepside plus praziquantel tablets (Profender® tablets for dogs) against mature adult, immature adult and larval stages of Toxocara canis and Toxascaris leonina was evaluated in ten randomised, blinded and placebo-controlled dose confirmation studies in naturally or experimentally...
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| Published in: | Parasitology research (1987) 2009-08, Vol.105 (1), p.1-8 |
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| Main Authors: | , , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c3357-39bbda726ca2d9b047bfdd338b0ec99fdb6408b65f9c17197324614c1465bb193 |
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| cites | cdi_FETCH-LOGICAL-c3357-39bbda726ca2d9b047bfdd338b0ec99fdb6408b65f9c17197324614c1465bb193 |
| container_end_page | 8 |
| container_issue | 1 |
| container_start_page | 1 |
| container_title | Parasitology research (1987) |
| container_volume | 105 |
| creator | Altreuther, Gertraut Schimmel, Annette Schroeder, Iris Bach, Thomas Charles, Samuel Kok, Dawid J Kraemer, Friederike Wolken, Sonja Young, David Krieger, Klemens J |
| description | The efficacy of emodepside plus praziquantel tablets (Profender® tablets for dogs) against mature adult, immature adult and larval stages of Toxocara canis and Toxascaris leonina was evaluated in ten randomised, blinded and placebo-controlled dose confirmation studies in naturally or experimentally infected dogs. The tablets were used at the proposed minimum dose of 1 mg emodepside and 5 mg praziquantel per kg body weight. Efficacy was calculated based on worm counts after necropsy. Five studies demonstrated >99% efficacy against mature adult, >92% efficacy against immature adult, >98% efficacy against L4 and >94% efficacy against L3 larval stages of T. canis. Another five studies demonstrated >99% efficacy against mature and immature adult and >95% efficacy against L4 larval stages of T. leonina. No side effects of the treatment were observed. Emodepside plus praziquantel tablets thus provide a comprehensive new treatment option for ascarid infections in the dog. |
| doi_str_mv | 10.1007/s00436-009-1489-7 |
| format | article |
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The tablets were used at the proposed minimum dose of 1 mg emodepside and 5 mg praziquantel per kg body weight. Efficacy was calculated based on worm counts after necropsy. Five studies demonstrated >99% efficacy against mature adult, >92% efficacy against immature adult, >98% efficacy against L4 and >94% efficacy against L3 larval stages of T. canis. Another five studies demonstrated >99% efficacy against mature and immature adult and >95% efficacy against L4 larval stages of T. leonina. No side effects of the treatment were observed. Emodepside plus praziquantel tablets thus provide a comprehensive new treatment option for ascarid infections in the dog.</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s00436-009-1489-7</identifier><identifier>PMID: 19575219</identifier><identifier>CODEN: PARREZ</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Administration, Oral ; adults ; adverse effects ; Animals ; Anthelmintics - administration & dosage ; Anthelmintics - adverse effects ; Anthelmintics - therapeutic use ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; body weight ; Depsipeptides - administration & dosage ; Depsipeptides - therapeutic use ; Dog Diseases - drug therapy ; Dog Diseases - parasitology ; Dogs ; Double-Blind Method ; Feces - parasitology ; Fundamental and applied biological sciences. Psychology ; General aspects ; General aspects and techniques. Study of several systematic groups. Models ; Immunology ; Invertebrates ; Medical Microbiology ; Microbiology ; Parasite Egg Count ; Placebos - administration & dosage ; praziquantel ; Praziquantel - administration & dosage ; Praziquantel - therapeutic use ; Tablets - administration & dosage ; Tablets - therapeutic use ; Toxascariasis - drug therapy ; Toxascariasis - veterinary ; Toxascaris - drug effects ; Toxascaris leonina ; Toxocara canis ; Treatment Outcome</subject><ispartof>Parasitology research (1987), 2009-08, Vol.105 (1), p.1-8</ispartof><rights>Springer-Verlag 2009</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3357-39bbda726ca2d9b047bfdd338b0ec99fdb6408b65f9c17197324614c1465bb193</citedby><cites>FETCH-LOGICAL-c3357-39bbda726ca2d9b047bfdd338b0ec99fdb6408b65f9c17197324614c1465bb193</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,777,781,786,787,23911,23912,25121,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21853827$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19575219$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Altreuther, Gertraut</creatorcontrib><creatorcontrib>Schimmel, Annette</creatorcontrib><creatorcontrib>Schroeder, Iris</creatorcontrib><creatorcontrib>Bach, Thomas</creatorcontrib><creatorcontrib>Charles, Samuel</creatorcontrib><creatorcontrib>Kok, Dawid J</creatorcontrib><creatorcontrib>Kraemer, Friederike</creatorcontrib><creatorcontrib>Wolken, Sonja</creatorcontrib><creatorcontrib>Young, David</creatorcontrib><creatorcontrib>Krieger, Klemens J</creatorcontrib><title>Efficacy of Emodepside plus Praziquantel Tablets (Profender® Tablets for Dogs) against Mature and Immature Infections with Toxocara canis and Toxascaris leonina in Dogs</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><addtitle>Parasitol Res</addtitle><description>The efficacy of emodepside plus praziquantel tablets (Profender® tablets for dogs) against mature adult, immature adult and larval stages of Toxocara canis and Toxascaris leonina was evaluated in ten randomised, blinded and placebo-controlled dose confirmation studies in naturally or experimentally infected dogs. The tablets were used at the proposed minimum dose of 1 mg emodepside and 5 mg praziquantel per kg body weight. Efficacy was calculated based on worm counts after necropsy. Five studies demonstrated >99% efficacy against mature adult, >92% efficacy against immature adult, >98% efficacy against L4 and >94% efficacy against L3 larval stages of T. canis. Another five studies demonstrated >99% efficacy against mature and immature adult and >95% efficacy against L4 larval stages of T. leonina. No side effects of the treatment were observed. Emodepside plus praziquantel tablets thus provide a comprehensive new treatment option for ascarid infections in the dog.</description><subject>Administration, Oral</subject><subject>adults</subject><subject>adverse effects</subject><subject>Animals</subject><subject>Anthelmintics - administration & dosage</subject><subject>Anthelmintics - adverse effects</subject><subject>Anthelmintics - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>body weight</subject><subject>Depsipeptides - administration & dosage</subject><subject>Depsipeptides - therapeutic use</subject><subject>Dog Diseases - drug therapy</subject><subject>Dog Diseases - parasitology</subject><subject>Dogs</subject><subject>Double-Blind Method</subject><subject>Feces - parasitology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects</subject><subject>General aspects and techniques. Study of several systematic groups. Models</subject><subject>Immunology</subject><subject>Invertebrates</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Parasite Egg Count</subject><subject>Placebos - administration & dosage</subject><subject>praziquantel</subject><subject>Praziquantel - administration & dosage</subject><subject>Praziquantel - therapeutic use</subject><subject>Tablets - administration & dosage</subject><subject>Tablets - therapeutic use</subject><subject>Toxascariasis - drug therapy</subject><subject>Toxascariasis - veterinary</subject><subject>Toxascaris - drug effects</subject><subject>Toxascaris leonina</subject><subject>Toxocara canis</subject><subject>Treatment Outcome</subject><issn>0932-0113</issn><issn>1432-1955</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAUhSMEokPhAdiAN0iwCPgvdrysygAjFVGJ6dry7-AqsQc7EZQ3YsND8GR4mlFZwcq-955zrPu5aZ4i-BpByN8UCClhLYSiRbQXLb_XrBAluEWi6-43KyjqHSJETppHpVxDiDij9GFzUue8w0ismp9r74NR5gYkD9Zjsm5fgnVgP8wFXGb1I3ydVZzcALZKD24q4OVlTt5F6_LvX3dNnzJ4m3blFVA7FWKZwEc1zdkBFS3YjONSbKJ3ZgopFvAtTF_ANn1PRmUFjIqh3GprS5Xaq-XgUgxRgRBvox83D7waintyPE-bq3fr7fmH9uLT-8352UVrCOl4S4TWVnHMjMJWaEi59tYS0mvojBDeakZhr1nnhUEcCU4wZYgaRFmnNRLktEFLrsmplOy83OcwqnwjEZQH7HLBLit2ecAuefU8Wzz7WY_O_nUcOVfBi6PgsN3gs4omlDsdRn1HenwIwouu1FHcuSyv05xj3fe_rz9fTF4lqXaVnbz6jCGiEEJWf5_-U0EgYh3CrCN_APKkr-w</recordid><startdate>200908</startdate><enddate>200908</enddate><creator>Altreuther, Gertraut</creator><creator>Schimmel, Annette</creator><creator>Schroeder, Iris</creator><creator>Bach, Thomas</creator><creator>Charles, Samuel</creator><creator>Kok, Dawid J</creator><creator>Kraemer, Friederike</creator><creator>Wolken, Sonja</creator><creator>Young, David</creator><creator>Krieger, Klemens J</creator><general>Berlin/Heidelberg : Springer-Verlag</general><general>Springer-Verlag</general><general>Springer</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200908</creationdate><title>Efficacy of Emodepside plus Praziquantel Tablets (Profender® Tablets for Dogs) against Mature and Immature Infections with Toxocara canis and Toxascaris leonina in Dogs</title><author>Altreuther, Gertraut ; Schimmel, Annette ; Schroeder, Iris ; Bach, Thomas ; Charles, Samuel ; Kok, Dawid J ; Kraemer, Friederike ; Wolken, Sonja ; Young, David ; Krieger, Klemens J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3357-39bbda726ca2d9b047bfdd338b0ec99fdb6408b65f9c17197324614c1465bb193</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Administration, Oral</topic><topic>adults</topic><topic>adverse effects</topic><topic>Animals</topic><topic>Anthelmintics - administration & dosage</topic><topic>Anthelmintics - adverse effects</topic><topic>Anthelmintics - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>body weight</topic><topic>Depsipeptides - administration & dosage</topic><topic>Depsipeptides - therapeutic use</topic><topic>Dog Diseases - drug therapy</topic><topic>Dog Diseases - parasitology</topic><topic>Dogs</topic><topic>Double-Blind Method</topic><topic>Feces - parasitology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects</topic><topic>General aspects and techniques. Study of several systematic groups. Models</topic><topic>Immunology</topic><topic>Invertebrates</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>Parasite Egg Count</topic><topic>Placebos - administration & dosage</topic><topic>praziquantel</topic><topic>Praziquantel - administration & dosage</topic><topic>Praziquantel - therapeutic use</topic><topic>Tablets - administration & dosage</topic><topic>Tablets - therapeutic use</topic><topic>Toxascariasis - drug therapy</topic><topic>Toxascariasis - veterinary</topic><topic>Toxascaris - drug effects</topic><topic>Toxascaris leonina</topic><topic>Toxocara canis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Altreuther, Gertraut</creatorcontrib><creatorcontrib>Schimmel, Annette</creatorcontrib><creatorcontrib>Schroeder, Iris</creatorcontrib><creatorcontrib>Bach, Thomas</creatorcontrib><creatorcontrib>Charles, Samuel</creatorcontrib><creatorcontrib>Kok, Dawid J</creatorcontrib><creatorcontrib>Kraemer, Friederike</creatorcontrib><creatorcontrib>Wolken, Sonja</creatorcontrib><creatorcontrib>Young, David</creatorcontrib><creatorcontrib>Krieger, Klemens J</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Parasitology research (1987)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Altreuther, Gertraut</au><au>Schimmel, Annette</au><au>Schroeder, Iris</au><au>Bach, Thomas</au><au>Charles, Samuel</au><au>Kok, Dawid J</au><au>Kraemer, Friederike</au><au>Wolken, Sonja</au><au>Young, David</au><au>Krieger, Klemens J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Emodepside plus Praziquantel Tablets (Profender® Tablets for Dogs) against Mature and Immature Infections with Toxocara canis and Toxascaris leonina in Dogs</atitle><jtitle>Parasitology research (1987)</jtitle><stitle>Parasitol Res</stitle><addtitle>Parasitol Res</addtitle><date>2009-08</date><risdate>2009</risdate><volume>105</volume><issue>1</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><coden>PARREZ</coden><abstract>The efficacy of emodepside plus praziquantel tablets (Profender® tablets for dogs) against mature adult, immature adult and larval stages of Toxocara canis and Toxascaris leonina was evaluated in ten randomised, blinded and placebo-controlled dose confirmation studies in naturally or experimentally infected dogs. The tablets were used at the proposed minimum dose of 1 mg emodepside and 5 mg praziquantel per kg body weight. Efficacy was calculated based on worm counts after necropsy. Five studies demonstrated >99% efficacy against mature adult, >92% efficacy against immature adult, >98% efficacy against L4 and >94% efficacy against L3 larval stages of T. canis. Another five studies demonstrated >99% efficacy against mature and immature adult and >95% efficacy against L4 larval stages of T. leonina. No side effects of the treatment were observed. Emodepside plus praziquantel tablets thus provide a comprehensive new treatment option for ascarid infections in the dog.</abstract><cop>Berlin/Heidelberg</cop><pub>Berlin/Heidelberg : Springer-Verlag</pub><pmid>19575219</pmid><doi>10.1007/s00436-009-1489-7</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0932-0113 |
| ispartof | Parasitology research (1987), 2009-08, Vol.105 (1), p.1-8 |
| issn | 0932-0113 1432-1955 |
| language | eng |
| recordid | cdi_crossref_primary_10_1007_s00436_009_1489_7 |
| source | Springer Nature |
| subjects | Administration, Oral adults adverse effects Animals Anthelmintics - administration & dosage Anthelmintics - adverse effects Anthelmintics - therapeutic use Biological and medical sciences Biomedical and Life Sciences Biomedicine body weight Depsipeptides - administration & dosage Depsipeptides - therapeutic use Dog Diseases - drug therapy Dog Diseases - parasitology Dogs Double-Blind Method Feces - parasitology Fundamental and applied biological sciences. Psychology General aspects General aspects and techniques. Study of several systematic groups. Models Immunology Invertebrates Medical Microbiology Microbiology Parasite Egg Count Placebos - administration & dosage praziquantel Praziquantel - administration & dosage Praziquantel - therapeutic use Tablets - administration & dosage Tablets - therapeutic use Toxascariasis - drug therapy Toxascariasis - veterinary Toxascaris - drug effects Toxascaris leonina Toxocara canis Treatment Outcome |
| title | Efficacy of Emodepside plus Praziquantel Tablets (Profender® Tablets for Dogs) against Mature and Immature Infections with Toxocara canis and Toxascaris leonina in Dogs |
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