Cytomegalovirus reactivation after low-dose steroid treatment for hemolytic anemia in a patient with primary Epstein-Barr virus infection

Cytomegalovirus reactivation is a well described event occurring after intensive therapeutic suppression of the immune function in patients with latent infection. Treatment protocols for suppression of the immune response often include high-dose steroids. However, it is not known whether even a low-...

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Bibliographic Details
Published in:Wiener Klinische Wochenschrift 2007-07, Vol.119 (13-14), p.435-437
Main Authors: Troselj-Vukic, Biserka, Milotic, Irena, Milotic, Franko, Crnic-Martinovic, Marija, Grahovac, Blazenka
Format: Article
Language:English
Subjects:
Adult
Anemia, Hemolytic, Autoimmune - drug therapy
Anemia, Hemolytic, Autoimmune - immunology
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - adverse effects
Cytomegalovirus - drug effects
Cytomegalovirus - genetics
Cytomegalovirus - immunology
Cytomegalovirus Infections - chemically induced
Cytomegalovirus Infections - immunology
DNA, Viral - blood
Dose-Response Relationship, Drug
Herpesvirus 4, Human - genetics
Herpesvirus 4, Human - immunology
Humans
Infectious Mononucleosis - complications
Infectious Mononucleosis - immunology
Long-Term Care
Male
Methylprednisolone - administration & dosage
Methylprednisolone - adverse effects
Opportunistic Infections - chemically induced
Opportunistic Infections - immunology
Polymerase Chain Reaction
Virus Activation - drug effects
Virus Activation - immunology
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Summary:Cytomegalovirus reactivation is a well described event occurring after intensive therapeutic suppression of the immune function in patients with latent infection. Treatment protocols for suppression of the immune response often include high-dose steroids. However, it is not known whether even a low-dose steroid treatment can reactivate latent cytomegalovirus in otherwise healthy persons. We documented cytomegalovirus reactivation after low-dose steroid treatment for autoimmune hemolytic anemia as a complication of Epstein-Barr virus mononucleosis in an immunocompetent 21-year-old man.
ISSN:0043-5325
1613-7671
DOI:10.1007/s00508-007-0821-4