Synergism between quinine and retinol in fresh isolates of Plasmodium falciparum

Summary Following earlier reports of synergism between retinol and various antimalarial compounds, the pharmacodynamic interaction between retinol and quinine was investigated in 38 fresh isolates of Plasmodium falciparum . The study was carried out in western Thailand, an area with quinine-resistan...

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Bibliographic Details
Published in:Wiener Klinische Wochenschrift 2008, Vol.120 (Suppl 4), p.69-73
Main Authors: Knauer, Ariane, Congpuong, Kanungnit, Wernsdorfer, Gunther, Reinthaler, Franz F., Sirichaisinthop, Jeeraphat, Wernsdorfer, Walther H.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Antimalarials - chemistry
Antimalarials - pharmacology
Antimalarials - therapeutic use
Child
Dose-Response Relationship, Drug
Drug Resistance
Drug Synergism
Endocrinology
Female
Gastroenterology
Humans
In Vitro Techniques
Internal Medicine
Malaria, Falciparum - drug therapy
Malaria, Falciparum - parasitology
Male
Medicine
Medicine & Public Health
Middle Aged
Myanmar
Original Article
Parasitic Sensitivity Tests
Plasmodium falciparum - drug effects
Pneumology/Respiratory System
Quinine - chemistry
Quinine - pharmacology
Quinine - therapeutic use
Thailand
Vitamin A - chemistry
Vitamin A - pharmacology
Vitamin A - therapeutic use
Vitamins - chemistry
Vitamins - pharmacology
Vitamins - therapeutic use
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Summary:Summary Following earlier reports of synergism between retinol and various antimalarial compounds, the pharmacodynamic interaction between retinol and quinine was investigated in 38 fresh isolates of Plasmodium falciparum . The study was carried out in western Thailand, an area with quinine-resistant P. falciparum . The combination of quinine with retinol in concentrations corresponding to the 50 th , 65 th and 80 th percentile of the physiological values in healthy subjects, significantly reduced the EC 50 , EC 90 , EC 99 and GMCOC for quinine. The FIC values at EC 90 and EC 99 indicate increasing synergism with rising EC and retinol concentration. The mean SFIC value dropped to a level as low as 0.2420, indicating strong synergism
ISSN:0043-5325
1613-7671
DOI:10.1007/s00508-008-1078-2