Post-reexposure administration of d-cycloserine facilitates reconsolidation of contextual conditioned fear memory in rats

The effect of d -cycloserine, a N -methyl- d -aspartate receptor partial agonist, on the reconsolidation of conditioned fear memory is not precisely understood. In this study, we clarified the effects of d -cycloserine on the reconsolidation in rats, by performing contextual fear conditioning with a...

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Bibliographic Details
Published in:Journal of Neural Transmission 2017-05, Vol.124 (5), p.583-587
Main Authors: Saitoh, Akiyoshi, Akagi, Kie, Oka, Jun-Ichiro, Yamada, Mitsuhiko
Format: Article
Language:English
Subjects:
Animals
Conditioning, Classical - drug effects
Cycloserine - administration & dosage
Extinction, Psychological - drug effects
Fear - drug effects
Freezing Reaction, Cataleptic - drug effects
Male
Medicine
Medicine & Public Health
Memory Consolidation - drug effects
Midazolam - administration & dosage
Neurology
Neurosciences
Nootropic Agents - administration & dosage
Psychiatry
Psychiatry and Preclinical Psychiatric Studies - Short communication
Rats, Wistar
Time Factors
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Summary:The effect of d -cycloserine, a N -methyl- d -aspartate receptor partial agonist, on the reconsolidation of conditioned fear memory is not precisely understood. In this study, we clarified the effects of d -cycloserine on the reconsolidation in rats, by performing contextual fear conditioning with a mild fear-conditioning procedure and with post-reexposure administration of the drug. The d -cycloserine (15 mg/kg subcutaneously)-treated rats showed a persistent and greater fear response during the test session compared with the control group. In conclusion, we have confirmed that post-reexposure administration of d -cycloserine facilitates the reconsolidation of fear memory in rats.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-017-1704-0