An inducible MAO-B mouse model of Parkinson’s disease: a tool towards better understanding basic disease mechanisms and developing novel therapeutics

Several studies have suggested that increases in astrocytic monoamine oxidase B (MAO-B) levels in conjunction with Parkinson’s disease (PD) may contribute to subsequent neuropathology associated with the disorder. MAO-B inhibitors are currently widely used as symptomatic therapeutics for PD and, alt...

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Bibliographic Details
Published in:Journal of Neural Transmission 2018-11, Vol.125 (11), p.1651-1658
Main Authors: Chamoli, Manish, Chinta, Shankar J., Andersen, Julie K.
Format: Article
Language:English
Subjects:
Medicine
Medicine & Public Health
Neurology
Neurology and Preclinical Neurological Studies - Review Article
Neurosciences
Psychiatry
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Summary:Several studies have suggested that increases in astrocytic monoamine oxidase B (MAO-B) levels in conjunction with Parkinson’s disease (PD) may contribute to subsequent neuropathology associated with the disorder. MAO-B inhibitors are currently widely used as symptomatic therapeutics for PD and, although somewhat controversial, these drugs may also exhibit disease-modifying properties. To obtain a better understanding of the potential role of MAO-B in disease neuropathology, we created an inducible astrocyte-specific transgenic MAO-B mouse model. Here, we summarize findings associated with this model, including neuropathological PD features associated with it.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-018-1887-z