The neural structures of theory of mind are valence-sensitive: evidence from three tDCS studies

• Published in: Journal of Neural Transmission 2024-09, Vol.131 (9), p.1067-1078
• Main Authors: Nejati, Vahid, Sharifian, Maryam, Famininejad, Zahra, Salehinejad, Mohammad Ali, Mahdian, Shahab
• Format: Article
• Language: English
• Subjects: Adult; Dorsolateral Prefrontal Cortex - physiology; Female; Humans; Male; Medicine; Medicine & Public Health; Neurology; Neurosciences; Prefrontal Cortex - physiology; Psychiatry; Psychiatry and Preclinical Psychiatric Studies - Original Article; Reaction Time - physiology; Theory of Mind - physiology; Transcranial Direct Current Stimulation; Young Adult
• ISSN: 0300-9564; 1435-1463; 1435-1463
• DOI: 10.1007/s00702-024-02808-9

Several cortical structures are involved in theory of mind (ToM), including the dorsolateral prefrontal cortex (dlPFC), the ventromedial prefrontal cortex (vmPFC), and the right temporo- parietal junction (rTPJ). We investigated the role of these regions in mind reading with respect to the valence of mental states. Sixty-five healthy adult participants were recruited and received transcranial direct current stimulation (tDCS) (1.5 mA, 20 min) with one week interval in three separate studies. The stimulation conditions were anodal tDCS over the dlPFC coupled with cathodal tDCS over the vmPFC, reversed stimulation conditions, and sham in the first study, and anodal tDCS over the vmPFC, or dlPFC, and sham stimulation, with an extracranial return electrode in the second and third study. During stimulation, participants underwent the reading mind from eyes/voice tests (RMET or RMVT) in each stimulation condition. Anodal left dlPFC/cathodal right vmPFC stimulation increased the accuracy of negative mental state attributions, anodal rTPJ decreased the accuracy of negative and neutral mental state attributions, and decreased the reaction time of positive mental state attributions. Our results imply that the neural correlates of ToM are valence-sensitive.