Synthesis of benzohetero[3, 2-a]pyrimidines using cyclic β-keto lactone as a building block

A novel method for the synthesis of 3-(2-substituted ethyl)-2-methylbenzohetero[3,2- a ]pyrimidines in high yield (80–85%) was achieved, which involves a dihydrofuranone intermediate, readily obtained from β-ketolactone to 2-aminobenzoheterocycles. The major advantage of the methodology is the high...

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Bibliographic Details
Published in:Monatshefte für Chemie 2009-02, Vol.140 (2), p.235-241
Main Authors: Toche, Raghunath B., Ghotekar, Bhausaheb K., Kazi, Muddassar A., Jachak, Madhukar N.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
Theoretical and Computational Chemistry
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Summary:A novel method for the synthesis of 3-(2-substituted ethyl)-2-methylbenzohetero[3,2- a ]pyrimidines in high yield (80–85%) was achieved, which involves a dihydrofuranone intermediate, readily obtained from β-ketolactone to 2-aminobenzoheterocycles. The major advantage of the methodology is the high yield and product purity. Graphical Abstract
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-008-0062-x