Synthesis and biological activities of novel ethers of quinolinone linked with coumarins

A series of new ethers of quinolinone linked with different substituted coumarins and benzofurans were synthesized from 4-(bromomethyl)quinolinones. All newly synthesized compounds were screened for their in vitro antibacterial and antifungal activities. Most of the compounds with chloro substitutio...

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Bibliographic Details
Published in:Monatshefte für Chemie 2011-03, Vol.142 (3), p.305-315
Main Authors: Kalkhambkar, Rajesh G., Aridoss, G., Kulkarni, Geeta M., Bapset, R. M., Mudaraddi, T. Y., Premkumar, N., Jeong, Yeon Tae
Format: Article
Language:English
Subjects:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
Theoretical and Computational Chemistry
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Summary:A series of new ethers of quinolinone linked with different substituted coumarins and benzofurans were synthesized from 4-(bromomethyl)quinolinones. All newly synthesized compounds were screened for their in vitro antibacterial and antifungal activities. Most of the compounds with chloro substitution at the C-6 or C-7 position in quinolinone showed potent antibacterial and antifungal activities. In pharmacological evaluations, some of these chloroquinolinones also showed 70–77% inhibition of inflammation after 8 h, whereas the other compounds showed 51–55% inhibition. Most of the compounds showed potent analgesic activity compared to the standard and control. The structures of all newly synthesized compounds were characterized by elemental analysis, IR, 1 H NMR, 13 C NMR, and EI-MS. Graphical abstract
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-011-0460-3