An improved catalytic method for the synthesis of 3,3-di(indolyl)oxindoles using Amberlyst 15 as a heterogeneous and reusable catalyst in water

Amberlyst 15 efficiently catalyzed the electrophilic substitution reaction of indoles with isatin derivatives to afford 3,3-di(indolyl)oxindoles in water. An important feature of this protocol is the reaction of 3-methyl-1 H -indole with isatins to give the corresponding 3,3-diaryloxindole derivativ...

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Bibliographic Details
Published in:Monatshefte für Chemie 2012-11, Vol.143 (11), p.1519-1522
Main Authors: Sarrafi, Yaghoub, Alimohammadi, Kamal, Sadatshahabi, Marzieh, Norozipoor, Nasibeh
Format: Article
Language:English
Subjects:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
Theoretical and Computational Chemistry
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Summary:Amberlyst 15 efficiently catalyzed the electrophilic substitution reaction of indoles with isatin derivatives to afford 3,3-di(indolyl)oxindoles in water. An important feature of this protocol is the reaction of 3-methyl-1 H -indole with isatins to give the corresponding 3,3-diaryloxindole derivatives in high yields. The catalyst exhibited remarkable reusable activity. Graphical Abstract .
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-012-0723-7