Imidazole functionalized magnetic Fe3O4 nanoparticles as a novel heterogeneous and efficient catalyst for synthesis of dihydropyrimidinones by Biginelli reaction

Dihydropyrimidinone derivatives were synthesized in moderate to high yields in one-pot three-component condensation reactions from the corresponding aldehydes, 1,3-dicarbonyl compounds, and urea in the presence of catalytic amounts of imidazole functionalized on magnetic nanoparticles as an efficien...

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Bibliographic Details
Published in:Monatshefte für Chemie 2013-12, Vol.144 (12), p.1877-1882
Main Authors: Nazari, Simin, Saadat, Shervin, Fard, Pegah Kazemian, Gorjizadeh, Maryam, Nezhad, Eshagh Rezaee, Afshari, Mozhgan
Format: Article
Language:English
Subjects:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Original Paper
Physical Chemistry
Theoretical and Computational Chemistry
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Summary:Dihydropyrimidinone derivatives were synthesized in moderate to high yields in one-pot three-component condensation reactions from the corresponding aldehydes, 1,3-dicarbonyl compounds, and urea in the presence of catalytic amounts of imidazole functionalized on magnetic nanoparticles as an efficient, non-toxic, reusable, and easily available catalyst under solvent-free conditions at 80 °C. Compared to the classical Biginelli reaction, this new method consistently has the advantage of excellent yields, short reaction times, and methodological simplicity. Furthermore, the nanomagnetic catalyst could be readily handled and removed from the reaction mixture via application of an external magnet, allowing straightforward recovery and reuse. Graphical Abstract .
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-013-1085-5